TY - JOUR
T1 - Nutritional status in pulmonary arterial hypertension
AU - Kwant, Chermaine T.
AU - van der Horst, Frans A. L.
AU - Bogaard, Harm J.
AU - de Man, Frances S.
AU - Vonk Noordegraaf, Anton
N1 - Funding Information: This research was funded by JB's Academy of Finland research fellowship Creation, genius, innovation: Towards a conceptual genealogy of Western creativity (2018–2023, Grant Number 317276). Background work was funded by Prof. Mika Ojakangas's Academy of Finland research project The intellectual heritage of radical cultural conservatism (2013–2017, Grant Number 267352). PM wishes to acknowledge the financial support of the Research Center in Political Science (CICP) at the University of Minho. Funding Information: We gratefully thank Mary Nicolau from the department of public health of the Amsterdam University Medical Centre for providing us information on interpreting data from the HELIUS food frequency questionnaire. This investigator-sponsored study was financially supported by Janssen-Cilag B.V. Publisher Copyright: © The Authors. Pulmonary Circulation published by John Wiley & Sons Ltd on behalf of Pulmonary Vascular Research Institute.
PY - 2022/10
Y1 - 2022/10
N2 - Nutritional deficiencies have been described in patients with pulmonary arterial hypertension (PAH), such as in iron and vitamin D. However, an extensive description of vitamin and mineral status is lacking and until now there is no data on dietary intake in PAH patients. We analyzed blood samples and determined nutritional intake using a food frequency questionnaire (HELIUS) in a cohort of prevalent PAH patients at a single center in Amsterdam, the Netherlands. Quality of life (QoL) was assessed by the SF-36 questionnaire. In total, 37 patients were included (6 males, 31 females; 48 ± 16 years). The dietary intake of sugar was above 25 g in 87% of the patients and fluid intake was above 1500 ml in 78% of the patients. Sodium intake was below 1800 mg in the majority (56%) of the patients. Sugar and fluid intake were linear related. We confirm previously observed deficiencies of iron and vitamin D in our study population. In addition, we observed a functional vitamin B12 deficiency in 29% of patients, which coincided with an increased expression of methylmalonic acid. 60% of patients had a low vitamin K1 status (<0.8 nmol/L). Finally, 40% of patients had selenium levels below <100 μg/L and low selenium levels associated with reduced vitality in these patients. Besides the known deficiencies in iron and vitamin D levels, we observed in a subset of patients signs of vitamin B12, vitamin K1 and selenium deficiencies. There is room for improving dietary intake. Future research aims to demonstrate the clinical importance and reveal the effect of nutritional interventions.
AB - Nutritional deficiencies have been described in patients with pulmonary arterial hypertension (PAH), such as in iron and vitamin D. However, an extensive description of vitamin and mineral status is lacking and until now there is no data on dietary intake in PAH patients. We analyzed blood samples and determined nutritional intake using a food frequency questionnaire (HELIUS) in a cohort of prevalent PAH patients at a single center in Amsterdam, the Netherlands. Quality of life (QoL) was assessed by the SF-36 questionnaire. In total, 37 patients were included (6 males, 31 females; 48 ± 16 years). The dietary intake of sugar was above 25 g in 87% of the patients and fluid intake was above 1500 ml in 78% of the patients. Sodium intake was below 1800 mg in the majority (56%) of the patients. Sugar and fluid intake were linear related. We confirm previously observed deficiencies of iron and vitamin D in our study population. In addition, we observed a functional vitamin B12 deficiency in 29% of patients, which coincided with an increased expression of methylmalonic acid. 60% of patients had a low vitamin K1 status (<0.8 nmol/L). Finally, 40% of patients had selenium levels below <100 μg/L and low selenium levels associated with reduced vitality in these patients. Besides the known deficiencies in iron and vitamin D levels, we observed in a subset of patients signs of vitamin B12, vitamin K1 and selenium deficiencies. There is room for improving dietary intake. Future research aims to demonstrate the clinical importance and reveal the effect of nutritional interventions.
KW - deficiencies
KW - diet
KW - nutrition
KW - pulmonary hypertension
UR - http://www.scopus.com/inward/record.url?scp=85145067457&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/pul2.12173
DO - https://doi.org/10.1002/pul2.12173
M3 - Article
C2 - 36568692
SN - 2045-8932
VL - 12
JO - PULMONARY CIRCULATION
JF - PULMONARY CIRCULATION
IS - 4
M1 - e12173
ER -