TY - JOUR
T1 - Nutritional support for extremely low-birth weight infants
T2 - Abandoning catabolism in the neonatal intensive care unit
AU - Van Den Akker, Chris Hp
AU - Vlaardingerbroek, Hester
AU - Van Goudoever, Johannes B.
PY - 2010/5
Y1 - 2010/5
N2 - Purpose of review: Obviously, the ultimate goal in neonatology is to achieve a functional outcome in premature infants that is comparable to healthy term-born infants. As nutrition is one of the key factors for normal cell growth, providing the right amount and quality of nutrients could prove pivotal for normal development. However, many premature infants are catabolic during the first week of life, which has directly been linked to growth failure, disease, and suboptimal long-term outcome. This review describes the progress in research on parenteral nutrition for premature infants with a focus on amino acids and the influence of nutrition on later outcome. Recent findings: Although randomized clinical trials on early nutrition for premature infants remain relatively sparse, evidence is accumulating on its beneficial effects both on the short-term and long-term. However, some research also warns for adverse effects. Summary: Despite the fact that substantially improved nutritional therapies for preterm neonates have been implemented, still, some reluctance exists when it comes to providing high amounts of nutrition to the most immature infants. Pros and cons are outlined, as well as deficits in knowledge, when it comes to providing the optimal nutrient strategy in the first postnatal phase.
AB - Purpose of review: Obviously, the ultimate goal in neonatology is to achieve a functional outcome in premature infants that is comparable to healthy term-born infants. As nutrition is one of the key factors for normal cell growth, providing the right amount and quality of nutrients could prove pivotal for normal development. However, many premature infants are catabolic during the first week of life, which has directly been linked to growth failure, disease, and suboptimal long-term outcome. This review describes the progress in research on parenteral nutrition for premature infants with a focus on amino acids and the influence of nutrition on later outcome. Recent findings: Although randomized clinical trials on early nutrition for premature infants remain relatively sparse, evidence is accumulating on its beneficial effects both on the short-term and long-term. However, some research also warns for adverse effects. Summary: Despite the fact that substantially improved nutritional therapies for preterm neonates have been implemented, still, some reluctance exists when it comes to providing high amounts of nutrition to the most immature infants. Pros and cons are outlined, as well as deficits in knowledge, when it comes to providing the optimal nutrient strategy in the first postnatal phase.
KW - Amino acids
KW - Neonatal intensive care unit
KW - Outcome
KW - Parenteral nutrition
KW - Premature infants
KW - Preterm neonates
KW - Protein metabolism
UR - http://www.scopus.com/inward/record.url?scp=77951498280&partnerID=8YFLogxK
U2 - https://doi.org/10.1097/MCO.0b013e328337d925
DO - https://doi.org/10.1097/MCO.0b013e328337d925
M3 - Review article
C2 - 20216411
SN - 1363-1950
VL - 13
SP - 327
EP - 335
JO - Current Opinion in Clinical Nutrition and Metabolic Care
JF - Current Opinion in Clinical Nutrition and Metabolic Care
IS - 3
ER -