TY - JOUR
T1 - Objective measurements for upper airway obstruction in infants with Robin sequence: what are we measuring? A systematic review
AU - Logjes, Robrecht J. H.
AU - MacLean, Joanna E.
AU - de Cort, Noor W.
AU - Poets, Christian F.
AU - Abadie, V. ronique
AU - Joosten, Koen F. M.
AU - Resnick, Cory M.
AU - Trindade-Suedam, Ivy K.
AU - Zdanski, Carlton J.
AU - Forrest, Christopher R.
AU - Kruisinga, Frea H.
AU - Flores, Roberto L.
AU - Evans, Kelly N.
AU - Breugem, Corstiaan C.
N1 - Publisher Copyright: © 2021 American Academy of Sleep Medicine.
PY - 2021/8/1
Y1 - 2021/8/1
N2 - Study Objectives: Identifying optimal treatment for infants with Robin sequence (RS) is challenging due to substantial variability in the presentation of upper airway obstruction (UAO) in this population.Objective assessments of UAOand treatments are not standardized. A systematic review of objectivemeasures ofUAO was conducted as a step toward evidence-based clinical decision-making for RS. Methods: A literature search was performed in the PubMed and Embase databases (1990-2020) following PRISMA guidelines. Articles reporting on RS and UAO treatment were included if the following objective measures were studied: Oximetry, polysomnography, and blood gas. Quality was appraised by the methodological index for nonrandomized studies (range: 0-24). Results: A total of 91 articles met the inclusion criteria. The mean methodological index for nonrandomized studies score was 7.1 (range: 3-14). Polysomnography was most frequently used (76%) followed by oximetry (20%) and blood gas (11%). Sleep position of the infantwas reported in 35%of studies, with supine position most frequently, and monitoring time in 42%, including overnight recordings, in more than half. Of 71 studies that evaluated UAO interventions, the majority used polysomnography (90%), of which 61% did not specify the polysomnography technique. Reported polysomnography metrics included oxygen saturation (61%), apnea-hypopnea index (52%), carbon dioxide levels (31%), obstructive apnea-hypopnea index (27%), and oxygen desaturation index (16%). Only 42 studies reported indications for UAO intervention, with oximetry and polysomnography thresholds used equally (both 40%). In total, 34 distinct indications for treatment were identified. Conclusions: This systematic review demonstrates a lack of standardization, interpretation, and reporting of assessment and treatment indications for UAO in RS. An international, multidisciplinary consensus protocol is needed to guide clinicians on optimal UAO assessment in RS.
AB - Study Objectives: Identifying optimal treatment for infants with Robin sequence (RS) is challenging due to substantial variability in the presentation of upper airway obstruction (UAO) in this population.Objective assessments of UAOand treatments are not standardized. A systematic review of objectivemeasures ofUAO was conducted as a step toward evidence-based clinical decision-making for RS. Methods: A literature search was performed in the PubMed and Embase databases (1990-2020) following PRISMA guidelines. Articles reporting on RS and UAO treatment were included if the following objective measures were studied: Oximetry, polysomnography, and blood gas. Quality was appraised by the methodological index for nonrandomized studies (range: 0-24). Results: A total of 91 articles met the inclusion criteria. The mean methodological index for nonrandomized studies score was 7.1 (range: 3-14). Polysomnography was most frequently used (76%) followed by oximetry (20%) and blood gas (11%). Sleep position of the infantwas reported in 35%of studies, with supine position most frequently, and monitoring time in 42%, including overnight recordings, in more than half. Of 71 studies that evaluated UAO interventions, the majority used polysomnography (90%), of which 61% did not specify the polysomnography technique. Reported polysomnography metrics included oxygen saturation (61%), apnea-hypopnea index (52%), carbon dioxide levels (31%), obstructive apnea-hypopnea index (27%), and oxygen desaturation index (16%). Only 42 studies reported indications for UAO intervention, with oximetry and polysomnography thresholds used equally (both 40%). In total, 34 distinct indications for treatment were identified. Conclusions: This systematic review demonstrates a lack of standardization, interpretation, and reporting of assessment and treatment indications for UAO in RS. An international, multidisciplinary consensus protocol is needed to guide clinicians on optimal UAO assessment in RS.
KW - Apnea-hypopnea index
KW - Blood gas
KW - Carbon dioxide
KW - Obstructive apnea-hypopnea index
KW - Obstructive sleep apnea
KW - Oximetry
KW - Oxygen desaturation index
KW - Oxygen saturation
KW - Polysomnography
UR - http://www.scopus.com/inward/record.url?scp=85111728538&partnerID=8YFLogxK
U2 - https://doi.org/10.5664/jcsm.9394
DO - https://doi.org/10.5664/jcsm.9394
M3 - Review article
C2 - 33960296
SN - 1550-9389
VL - 17
SP - 1717
EP - 1729
JO - Journal of clinical sleep medicine : JCSM
JF - Journal of clinical sleep medicine : JCSM
IS - 8
ER -