TY - JOUR
T1 - Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis: A Network Perspective
T2 - A Network Perspective
AU - Ong, Hui Lin
AU - Isvoranu, Adela-Maria
AU - Schirmbeck, Frederike
AU - McGuire, Philip
AU - Valmaggia, Lucia
AU - Kempton, Matthew J.
AU - van der Gaag, Mark
AU - Riecher-Rössler, Anita
AU - Bressan, Rodrigo A.
AU - Barrantes-Vidal, Neus
AU - Nelson, Barnaby
AU - Amminger, G. Paul
AU - McGorry, Patrick
AU - Pantelis, Christos
AU - Krebs, Marie-Odile
AU - Nordentoft, Merete
AU - Glenthøj, Birte
AU - Ruhrmann, Stephan
AU - Sachs, Gabriele
AU - Rutten, Bart P. F.
AU - van Os, Jim
AU - de Haan, Lieuwe
AU - Borsboom, Denny
AU - Calem, Maria
AU - Tognin, Stefania
AU - Modinos, Gemma
AU - Pisani, Sara
AU - Hedges, Emily
AU - Velthorst, Eva
AU - Kraan, Tamar C.
AU - van Dam, Daniella S.
AU - Burger, Nadine
AU - Politis, Athena
AU - Goodall, Joanne
AU - Borgwardt, Stefan
AU - Studerus, Erich
AU - Gadelha, Ary
AU - Brietzke, Elisa
AU - Asevedo, Graccielle
AU - Asevedo, Elson
AU - Zugman, Andre
AU - Domínguez-Martínez, Tecelli
AU - Monsonet, Manel
AU - Hinojosa, Lidia
AU - Racioppi, Anna
AU - Kwapil, Thomas R.
AU - Kazes, Mathilde
AU - Daban, Claire
AU - Bourgin, Julie
AU - Gay, Olivier
AU - Mam-Lam-Fook, C. lia
AU - Nordholm, Dorte
AU - Randers, Lasse
AU - Krakauer, Kristine
AU - Glenthøj, Louise Birkedal
AU - Gebhard, Dominika
AU - Arnhold, Julia
AU - Klosterkötter, Joachim
AU - Lasser, Iris
AU - Winklbaur, Bernadette
AU - Delespaul, Philippe A.
AU - EU-GEI High Risk Study
N1 - Publisher Copyright: © 2021 The Author(s) 2021. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.
PY - 2021/7/1
Y1 - 2021/7/1
N2 - Background: The high prevalence of obsessive-compulsive symptoms (OCS) among subjects at Ultra-High Risk (UHR) for psychosis is well documented. However, the network structure spanning the relations between OCS and symptoms of the at risk mental state for psychosis as assessed with the Comprehensive Assessment of At Risk Mental States (CAARMS) has not yet been investigated. This article aimed to use a network approach to investigate the associations between OCS and CAARMS symptoms in a large sample of individuals with different levels of risk for psychosis. Method: Three hundred and forty-one UHR and 66 healthy participants were included, who participated in the EU-GEI study. Data analysis consisted of constructing a network of CAARMS symptoms, investigating central items in the network, and identifying the shortest pathways between OCS and positive symptoms. Results: Strong associations between OCS and anxiety, social isolation and blunted affect were identified. Depression was the most central symptom in terms of the number of connections, and anxiety was a key item in bridging OCS to other symptoms. Shortest paths between OCS and positive symptoms revealed that unusual thought content and perceptual abnormalities were connected mainly via anxiety, while disorganized speech was connected via blunted affect and cognitive change. Conclusions: Findings provide valuable insight into the central role of depression and the potential connective component of anxiety between OCS and other symptoms of the network. Interventions specifically aimed to reduce affective symptoms might be crucial for the development and prospective course of symptom co-occurrence.
AB - Background: The high prevalence of obsessive-compulsive symptoms (OCS) among subjects at Ultra-High Risk (UHR) for psychosis is well documented. However, the network structure spanning the relations between OCS and symptoms of the at risk mental state for psychosis as assessed with the Comprehensive Assessment of At Risk Mental States (CAARMS) has not yet been investigated. This article aimed to use a network approach to investigate the associations between OCS and CAARMS symptoms in a large sample of individuals with different levels of risk for psychosis. Method: Three hundred and forty-one UHR and 66 healthy participants were included, who participated in the EU-GEI study. Data analysis consisted of constructing a network of CAARMS symptoms, investigating central items in the network, and identifying the shortest pathways between OCS and positive symptoms. Results: Strong associations between OCS and anxiety, social isolation and blunted affect were identified. Depression was the most central symptom in terms of the number of connections, and anxiety was a key item in bridging OCS to other symptoms. Shortest paths between OCS and positive symptoms revealed that unusual thought content and perceptual abnormalities were connected mainly via anxiety, while disorganized speech was connected via blunted affect and cognitive change. Conclusions: Findings provide valuable insight into the central role of depression and the potential connective component of anxiety between OCS and other symptoms of the network. Interventions specifically aimed to reduce affective symptoms might be crucial for the development and prospective course of symptom co-occurrence.
KW - anxiety
KW - clinical high risk
KW - depression
KW - network analysis
KW - obsessive-compulsive
KW - psychosis
KW - ultra-high risk
UR - http://www.scopus.com/inward/record.url?scp=85111024453&partnerID=8YFLogxK
UR - https://pure.uva.nl/ws/files/121440766/sbaa187_suppl_supplementary_materials.pdf
U2 - https://doi.org/10.1093/schbul/sbaa187
DO - https://doi.org/10.1093/schbul/sbaa187
M3 - Article
C2 - 33595089
SN - 0586-7614
VL - 47
SP - 1018
EP - 1028
JO - Schizophrenia Bulletin
JF - Schizophrenia Bulletin
IS - 4
ER -