TY - JOUR
T1 - Occupational and non-occupational allergic contact dermatitis: a follow-up study
AU - Macan, Jelena
AU - Rimac, Davor
AU - Kežić, Sanja
AU - Varnai, Veda Marija
PY - 2013
Y1 - 2013
N2 - The aim of this study was to obtain insight into the clinical course and prognosis of allergic contact dermatitis (ACD), including potential effects of genetic and environmental factors. Eighty-two patients with previously defined ACD acquired occupationally (OACD) or non-occupationally (NOACD) were patch retested and evaluated for the presence of persistent eczema, atopy and filaggrin mutations. The crude risk for the persistence of a positive patch test (PT) reaction was 6.3 times higher (95% CI 3.63-11.0) for PT reactions assessed as '+++' compared to '++' reactions at the first PT. Among the categories of OACD, NOACD, age, gender, atopy, and the number of positive PT reactions at the first and second PT, only OACD (OR 10.0, 95% CI 1.95-51.2) and number of positive PT reactions at retesting (OR 3.85, 95% CI 1.57-9.44) were found to be predictors of persistent eczema. Occupationally acquired contact allergy was emphasized as the most important factor in predicting poor prognosis of ACD
AB - The aim of this study was to obtain insight into the clinical course and prognosis of allergic contact dermatitis (ACD), including potential effects of genetic and environmental factors. Eighty-two patients with previously defined ACD acquired occupationally (OACD) or non-occupationally (NOACD) were patch retested and evaluated for the presence of persistent eczema, atopy and filaggrin mutations. The crude risk for the persistence of a positive patch test (PT) reaction was 6.3 times higher (95% CI 3.63-11.0) for PT reactions assessed as '+++' compared to '++' reactions at the first PT. Among the categories of OACD, NOACD, age, gender, atopy, and the number of positive PT reactions at the first and second PT, only OACD (OR 10.0, 95% CI 1.95-51.2) and number of positive PT reactions at retesting (OR 3.85, 95% CI 1.57-9.44) were found to be predictors of persistent eczema. Occupationally acquired contact allergy was emphasized as the most important factor in predicting poor prognosis of ACD
U2 - https://doi.org/10.1159/000354763
DO - https://doi.org/10.1159/000354763
M3 - Article
C2 - 24193097
SN - 1018-8665
VL - 227
SP - 321
EP - 329
JO - Dermatology (Basel, Switzerland)
JF - Dermatology (Basel, Switzerland)
IS - 4
ER -