TY - JOUR
T1 - Oesophageal baseline impedance values are decreased in patients with eosinophilic oesophagitis
AU - van Rhijn, Bram D.
AU - Kessing, Boudewijn F.
AU - Smout, Andreas J. P. M.
AU - Bredenoord, Albert J.
PY - 2013
Y1 - 2013
N2 - Background: Gastro-oesophageal reflux has been suggested to play a role in eosinophilic oesophagitis (EoO). Oesophageal acid exposure decreases baseline intraluminal impedance, a marker of mucosal integrity, in patients with gastro-oesophageal reflux disease (GORD). Objectives: The aim of this study was to assess oesophageal baseline impedance levels in EoO patients and to investigate their relationship with oesophageal acid exposure. Methods: Ambulatory 24-h pH-impedance monitoring was performed in 11 EoO patients and in 11 healthy controls with matched oesophageal acid exposure. We assessed baseline impedance levels in the distal, mid-, and proximal oesophageal impedance channels. Results: Baseline impedance levels in EoO patients were markedly lower compared to controls in the distal oesophagus (median (interquartile range): 988 (757-1978) vs. 2259 (1767-2896) Omega, p = 0.015), mid-oesophagus (1420 (836-2164) vs. 2614 (2374-3879) Omega, p = 0.003), and proximal oesophagus (1856 (1006-2625) vs. 2868 (2397-3439) Omega, p = 0.005). Whereas baseline impedance decreased from proximal to distal in healthy subjects (p = 0.037), no such gradient was seen in EoO patients (p = 0.123). Conclusions: Throughout the oesophagus, baseline impedance values are decreased in EoO patients, indicating impaired mucosal integrity. Our findings suggest that factors other than acid reflux are the cause of low baseline impedance in EoO
AB - Background: Gastro-oesophageal reflux has been suggested to play a role in eosinophilic oesophagitis (EoO). Oesophageal acid exposure decreases baseline intraluminal impedance, a marker of mucosal integrity, in patients with gastro-oesophageal reflux disease (GORD). Objectives: The aim of this study was to assess oesophageal baseline impedance levels in EoO patients and to investigate their relationship with oesophageal acid exposure. Methods: Ambulatory 24-h pH-impedance monitoring was performed in 11 EoO patients and in 11 healthy controls with matched oesophageal acid exposure. We assessed baseline impedance levels in the distal, mid-, and proximal oesophageal impedance channels. Results: Baseline impedance levels in EoO patients were markedly lower compared to controls in the distal oesophagus (median (interquartile range): 988 (757-1978) vs. 2259 (1767-2896) Omega, p = 0.015), mid-oesophagus (1420 (836-2164) vs. 2614 (2374-3879) Omega, p = 0.003), and proximal oesophagus (1856 (1006-2625) vs. 2868 (2397-3439) Omega, p = 0.005). Whereas baseline impedance decreased from proximal to distal in healthy subjects (p = 0.037), no such gradient was seen in EoO patients (p = 0.123). Conclusions: Throughout the oesophagus, baseline impedance values are decreased in EoO patients, indicating impaired mucosal integrity. Our findings suggest that factors other than acid reflux are the cause of low baseline impedance in EoO
U2 - https://doi.org/10.1177/2050640613496411
DO - https://doi.org/10.1177/2050640613496411
M3 - Article
C2 - 24917968
SN - 2050-6406
VL - 1
SP - 242
EP - 248
JO - United European gastroenterology journal
JF - United European gastroenterology journal
IS - 4
ER -