TY - JOUR
T1 - On development of functional brain connectivity in the young brain
AU - Hoff, G. E.Anna Jasmijn
AU - Van den Heuvel, M. P.
AU - Benders, Manon J.N.L.
AU - Kersbergen, Karina J.
AU - De Vries, L. S.
PY - 2013/10/8
Y1 - 2013/10/8
N2 - Our brain is a complex network of structurally and functionally interconnected regions, shaped to efficiently process and integrate information. The development from a brain equipped with basic functionalities to an efficient network facilitating complex behavior starts during gestation and continues into adulthood. Resting-state functional MRI(rs-fMRI) enables the examination of developmental aspects of functional connectivity (FC) and functional brain networks. This review will discuss changes observed in the developing brain on the level of network FC from a gestational age of 20 weeks onwards. We discuss findings of resting-state fMRI studies showing that functional network development starts during gestation, creating a foundation for each of the resting-state networks (RSNs) to be established. Visual and sensorimotor areas are reported to develop first, with other networks, at different rates, increasing both in network connectivity and size over time. Reaching childhood, marked fine-tuning and specialization takes place in the regions necessary for higher-order cognitive functions.
AB - Our brain is a complex network of structurally and functionally interconnected regions, shaped to efficiently process and integrate information. The development from a brain equipped with basic functionalities to an efficient network facilitating complex behavior starts during gestation and continues into adulthood. Resting-state functional MRI(rs-fMRI) enables the examination of developmental aspects of functional connectivity (FC) and functional brain networks. This review will discuss changes observed in the developing brain on the level of network FC from a gestational age of 20 weeks onwards. We discuss findings of resting-state fMRI studies showing that functional network development starts during gestation, creating a foundation for each of the resting-state networks (RSNs) to be established. Visual and sensorimotor areas are reported to develop first, with other networks, at different rates, increasing both in network connectivity and size over time. Reaching childhood, marked fine-tuning and specialization takes place in the regions necessary for higher-order cognitive functions.
KW - Brain development
KW - Functional connectivity
KW - Resting-state functional MRI
UR - http://www.scopus.com/inward/record.url?scp=84886418921&partnerID=8YFLogxK
U2 - https://doi.org/10.3389/fnhum.2013.00650
DO - https://doi.org/10.3389/fnhum.2013.00650
M3 - Review article
SN - 1662-5161
JO - Frontiers in human neuroscience
JF - Frontiers in human neuroscience
IS - OCT
M1 - 650
ER -