TY - JOUR
T1 - Oncofertility Perspectives for Girls with Cancer
AU - van der Perk, M. E. Madeleine
AU - van der Kooi, Anne-Lotte L. F.
AU - Bos, Annelies M. E.
AU - Broer, Simone L.
AU - Veening, Margreet A.
AU - van Leeuwen, Jeanette
AU - van Santen, Hanneke M.
AU - van Dorp, Wendy
AU - van den Heuvel-Eibrink, Marry M.
N1 - Funding Information: M.E.M. van der Perk is supported by funding from the Princess Máxima Center Foundation and Stichting Kinderoncologisch Centrum Rotterdam (sKOCR). Publisher Copyright: © 2022
PY - 2022/10/1
Y1 - 2022/10/1
N2 - Infertility is a serious early, as well as late, effect of childhood cancer treatment. If addressed in a timely manner at diagnosis, fertility preservation measures can be taken, preferably before the start of cancer treatment. However, pediatric oncologists might remain reluctant to offer counseling on fertility-preservation methods, although infrastructure to freeze ovarian tissue has become available and is currently considered standard care for pre- and postpubertal girls at high risk of gonadal damage. More importantly, risk factors have been identified for cancer treatment-related impairment of gonadal function, and the first successful pregnancies have been reported after autotransplanted ovarian tissue, which has been harvested from children. Additionally, great progress has been made in the field of ex vivo maturation of oocytes in frozen ovarian tissue, which provides opportunities for those at risk of ovarian micrometastasis. Hence, it is time to counsel girls at risk and make every effort to cryopreserve their ovarian tissue, now more than ever before.
AB - Infertility is a serious early, as well as late, effect of childhood cancer treatment. If addressed in a timely manner at diagnosis, fertility preservation measures can be taken, preferably before the start of cancer treatment. However, pediatric oncologists might remain reluctant to offer counseling on fertility-preservation methods, although infrastructure to freeze ovarian tissue has become available and is currently considered standard care for pre- and postpubertal girls at high risk of gonadal damage. More importantly, risk factors have been identified for cancer treatment-related impairment of gonadal function, and the first successful pregnancies have been reported after autotransplanted ovarian tissue, which has been harvested from children. Additionally, great progress has been made in the field of ex vivo maturation of oocytes in frozen ovarian tissue, which provides opportunities for those at risk of ovarian micrometastasis. Hence, it is time to counsel girls at risk and make every effort to cryopreserve their ovarian tissue, now more than ever before.
KW - Fertility preservation
KW - Ovarian tissue cryopreservation
KW - Ovarian tissue transplantation
KW - Pediatric oncology
UR - http://www.scopus.com/inward/record.url?scp=85139438216&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.jpag.2022.03.005
DO - https://doi.org/10.1016/j.jpag.2022.03.005
M3 - Editorial
C2 - 35358705
SN - 1083-3188
VL - 35
SP - 523
EP - 526
JO - Journal of pediatric and adolescent gynecology
JF - Journal of pediatric and adolescent gynecology
IS - 5
ER -