TY - JOUR
T1 - Optic axis uniformity as a metric to improve the contrast of birefringent structures and analyze the retinal nerve fiber layer in polarization-sensitive optical coherence tomography
AU - Willemse, Joy
AU - Gräfe, Maximilian G. O.
AU - van de Kreeke, Jacoba A.
AU - Feroldi, Fabio
AU - Verbraak, Frank D.
AU - de Boer, Johannes F.
PY - 2019/8/1
Y1 - 2019/8/1
N2 - A new metric is used to improve the contrast of birefringent structures in biological tissue using polarization-sensitive optical coherence tomography. This metric, optic axis uniformity (OAxU), is based on the optic axis of birefringence and quantifies the uniformity of the optic axis direction. OAxU provides surprisingly strong contrast for fibrous structures such as muscle and the retinal nerve fiber layer (RNFL). We used OAxU for automatic segmentation of the RNFL in human eyes. From the segmentation, en face images of RNFL thickness and RNFL birefringence were created. The measured birefringence values are consistent with earlier reports.
AB - A new metric is used to improve the contrast of birefringent structures in biological tissue using polarization-sensitive optical coherence tomography. This metric, optic axis uniformity (OAxU), is based on the optic axis of birefringence and quantifies the uniformity of the optic axis direction. OAxU provides surprisingly strong contrast for fibrous structures such as muscle and the retinal nerve fiber layer (RNFL). We used OAxU for automatic segmentation of the RNFL in human eyes. From the segmentation, en face images of RNFL thickness and RNFL birefringence were created. The measured birefringence values are consistent with earlier reports.
UR - http://www.mendeley.com/research/optic-axis-uniformity-metric-improve-contrast-birefringent-structures-analyze-retinal-nerve-fiber-la
UR - http://www.scopus.com/inward/record.url?scp=85070869106&partnerID=8YFLogxK
U2 - https://doi.org/10.1364/ol.44.003893
DO - https://doi.org/10.1364/ol.44.003893
M3 - Article
C2 - 31368995
SN - 0146-9592
VL - 44
SP - 3893
EP - 3896
JO - Optics Letters
JF - Optics Letters
IS - 15
ER -