Optimal Vitamin D Status: A Critical Analysis on the Basis of Evidence-Based Medicine

R. Bouillon, N.M. van Schoor, E. Gielen, S. Boonen, C. Mathieu, D. Vanderschueren, P.T.A.M. Lips

Research output: Contribution to journalArticleAcademicpeer-review

231 Citations (Scopus)


Context: Public health authorities around the world recommend widely variable supplementation strategies for adults, whereas several professional organizations, including The Endocrine Society, recommend higher supplementation. Methods: We analyzed published randomized controlled clinical trials to define the optimal intake or vitamin D status for bone and extra skeletal health. Conclusions: The extra skeletal effects of vitamin D are plausible as based on preclinical data and observational studies. However, a part from the beneficial effectsof800IU/dofvitaminD
Original languageEnglish
Pages (from-to)E1283-E1304
JournalJournal of clinical endocrinology and metabolism
Issue number8
Publication statusPublished - 2013

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