TY - JOUR
T1 - Optimising treatment strategies in spinal ependymoma based on 20 years of experience at a single centre
AU - Keil, Vera C.
AU - Schmitt, Anne J.
AU - Martin, Sean C.
AU - Cadoux-Hudson, Tom A. D.
AU - Pereira, Erlick A. C.
N1 - Copyright © 2016 Elsevier Ltd. All rights reserved.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Spinal ependymomas are rare tumours, with total resection favoured where possible. Several case series assessing the outcome following neurosurgical treatment for spinal ependymoma advocate the usage of adjuvant radiotherapy in cases of subtotal resection, or in unencapsulated tumours. We assessed the outcome of 61 consecutive cases of spinal ependymoma in a single centre over a 20 year period using a variety of outcome measures. Sex distribution was equal, with a mean age at surgery of 43.6 years (range 5-76 years). Overall, most tumours occurred in the lumbosacral region (70.5%), with fewer in the thoracic (27.9%) and cervical regions (18.0%). Myxopapillary features were seen in 41.0% of tumours, and were more common when occurring in the lumbar region (51.2%). Gross total resection was achieved in 52.5%, subtotal resection in 37.7% and biopsy alone in 9.8% of patients and 31.1% received adjuvant radiotherapy. Two-thirds of patients achieved an excellent post-operative neurological outcome (Frankel grade E). Tumour recurrence was rare. Gross total resection and good preoperative neurological condition were most strongly predictive of good outcome. Post-operative radiotherapy did not seem to confer survival benefit in this case series, even in cases of incomplete resection, leading us to question its utility for all cases of spinal cord ependymoma.
AB - Spinal ependymomas are rare tumours, with total resection favoured where possible. Several case series assessing the outcome following neurosurgical treatment for spinal ependymoma advocate the usage of adjuvant radiotherapy in cases of subtotal resection, or in unencapsulated tumours. We assessed the outcome of 61 consecutive cases of spinal ependymoma in a single centre over a 20 year period using a variety of outcome measures. Sex distribution was equal, with a mean age at surgery of 43.6 years (range 5-76 years). Overall, most tumours occurred in the lumbosacral region (70.5%), with fewer in the thoracic (27.9%) and cervical regions (18.0%). Myxopapillary features were seen in 41.0% of tumours, and were more common when occurring in the lumbar region (51.2%). Gross total resection was achieved in 52.5%, subtotal resection in 37.7% and biopsy alone in 9.8% of patients and 31.1% received adjuvant radiotherapy. Two-thirds of patients achieved an excellent post-operative neurological outcome (Frankel grade E). Tumour recurrence was rare. Gross total resection and good preoperative neurological condition were most strongly predictive of good outcome. Post-operative radiotherapy did not seem to confer survival benefit in this case series, even in cases of incomplete resection, leading us to question its utility for all cases of spinal cord ependymoma.
KW - Adolescent
KW - Adult
KW - Child
KW - Ependymoma/pathology
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Outcome Assessment, Health Care/statistics & numerical data
KW - Retrospective Studies
KW - Spinal Cord Neoplasms/pathology
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84961116471&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/26944215
U2 - https://doi.org/10.1016/j.jocn.2016.01.003
DO - https://doi.org/10.1016/j.jocn.2016.01.003
M3 - Article
C2 - 26944215
SN - 0967-5868
VL - 29
SP - 52
EP - 58
JO - Journal of clinical neuroscience
JF - Journal of clinical neuroscience
ER -