TY - JOUR
T1 - Oral and laryngeal HPV infection: Incidence, prevalence and risk factors, with special regard to concurrent infection in head, neck and genitals
AU - Wierzbicka, Malgorzata
AU - Klussmann, Jens Peter
AU - San Giorgi, Michel R.
AU - Wuerdemann, Nora
AU - Dikkers, Frederik G.
N1 - Publisher Copyright: © 2021 The Author(s)
PY - 2021/4/22
Y1 - 2021/4/22
N2 - This review focuses on the importance of oral and laryngeal HPV infection which is present in majority of sexually active individuals at least once in their lifetime. Despite testing, still little is known about prevalence rates, determinants and, especially, the concurrent HPV infection in head and neck, and genitals. The purpose of this review is to clarify some issues of oral HPV incidence, prevalence, and to demonstrate the difficulties in identification of asymptomatic oral HPV carriers. The main premise to take up this topic is the high and still increasing risk for development of oropharyngeal cancer, and potential benefit from screening strategies, education programs and HPV vaccination. Transmission of HPV to the oral cavity and oropharynx is hypothesized to occur mainly through sexual contact. The exposure of oropharyngeal mucosa to HPV infection with consequence of increased risk for oropharyngeal carcinoma depends on specific sexual behavior. Male gender, older age, race or ethnicity, oral hygiene and current cigarette smoking are independently associated with any prevalent oral HPV infection.
AB - This review focuses on the importance of oral and laryngeal HPV infection which is present in majority of sexually active individuals at least once in their lifetime. Despite testing, still little is known about prevalence rates, determinants and, especially, the concurrent HPV infection in head and neck, and genitals. The purpose of this review is to clarify some issues of oral HPV incidence, prevalence, and to demonstrate the difficulties in identification of asymptomatic oral HPV carriers. The main premise to take up this topic is the high and still increasing risk for development of oropharyngeal cancer, and potential benefit from screening strategies, education programs and HPV vaccination. Transmission of HPV to the oral cavity and oropharynx is hypothesized to occur mainly through sexual contact. The exposure of oropharyngeal mucosa to HPV infection with consequence of increased risk for oropharyngeal carcinoma depends on specific sexual behavior. Male gender, older age, race or ethnicity, oral hygiene and current cigarette smoking are independently associated with any prevalent oral HPV infection.
KW - Concurrent oro-genital infection
KW - Contagiousness
KW - HPV
KW - Infection
KW - Larynx
KW - Oral
KW - Oropharynx
UR - http://www.scopus.com/inward/record.url?scp=85103730944&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.vaccine.2021.03.047
DO - https://doi.org/10.1016/j.vaccine.2021.03.047
M3 - Review article
C2 - 33812740
SN - 0264-410X
VL - 39
SP - 2344
EP - 2350
JO - Vaccine
JF - Vaccine
IS - 17
ER -