TY - JOUR
T1 - Oral health in patients scheduled for hematopoietic stem cell transplantation in the Orastem study
AU - Skallsjö, Kristina
AU - von Bültzingslöwen, Inger
AU - Hasséus, Bengt
AU - Johansson, Jan-Erik
AU - Öhman, Jenny
AU - Raber-Durlacher, Judith E.
AU - Huysmans, Marie-Charlotte D. N. J. M.
AU - Laheij, Alexa M. G. A.
AU - van Leeuwen, Stephanie J. M.
AU - Hovan, Allan J.
AU - Legert, Karin Garming
AU - Nguyen, Hieu M.
AU - Turk, Philip J.
AU - Rozema, Frederik R.
AU - Blijlevens, Nicole M. A.
AU - Brennan, Michael T.
N1 - Funding Information: This study was funded by grants from Stiftelsen Wilhelm och Martina Lundgrens Vetenskapsfond, https://wmlundgren.se/vetenskapsfonden/ (2020-3569) to B.H.; the Local Research and Development Council for Gothenburg and Södra Bohuslän Region Västra Götaland, https://www.researchweb.org/is/gsb (VGFOUGSB-932842) to K.S.; the Dutch Cancer Society, https://www.kwf.nl/ (ACTA 2014-7468; trial register NTR5760) to J.D., N.B., F.R., M.H.; Göteborgs Tandläkare-Sällskap, https://goteborgstandlakaresallskap.nu/ to K.S.; Stiftelsen Assar Gabrielssons´ Fond, https://www.agfond.se (FB20-23 and FB21-55) to K.S.; the Public Dental Health Organization in Värmland Region, https://www.regionvarmland.se/tandvard to I.v.B.; TUA Research Funding; the Sahlgrenska Academy at University of Gothenburg/Region Västra Götaland, https://www.researchweb.org/is/tuagbg (TUAGBG-135781) to I.v.B.; internal funding from Atrium Health Carolinas Medical Center, Charlotte, NC, https://atriumhealth.org/research to M.B. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors acknowledge the valuable contributions of Anders Grip for valuable help with establishing the database, Michelle Williams (in memorium) for support of the idea to initiate Orastem and the site-specific coordinators and staff for their dedicated work. Publisher Copyright: © 2023 Skallsjö et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2023/5/1
Y1 - 2023/5/1
N2 - Despite advances in transplant medicine, prevalence of complications after hematopoietic stem cell transplantation (HSCT) remains high. The impact of pre-HSCT oral health factors on the incidence and severity of complications post-HSCT is poorly understood. The aim of this prospective, observational study was to analyze oral health in patients planned for HSCT. Patients ≥18 years requiring HSCT were included from five sites between 2011–2018. General health, oral findings and patient-reported symptoms were registered in 272 patients. Oral symptoms around disease onset were reported by 43 patients (15.9%) and 153 patients (58.8%) reported oral complications during previous chemotherapy. One third of patients experienced oral symptoms at the oral examination before conditioning regimen and HSCT. In total, 124 (46.1%) patients had dental caries, 63 (29.0%) had ≥one tooth with deep periodontal pockets, 147 (75.0%) had ≥one tooth with bleeding on probing. Apical periodontitis was observed in almost 1/4 and partially impacted teeth in 17 (6.3%) patients. Oral mucosal lesions were observed in 84 patients (30.9%). A total of 45 (17.4%) of 259 patients had at least one acute issue to be managed prior to HSCT.symptoms and manifestations of oral disease were prevalent in patients planned for HSCT. The extent of oral and acute dental diseases calls for general oral screening of patients pre-HSCT.
AB - Despite advances in transplant medicine, prevalence of complications after hematopoietic stem cell transplantation (HSCT) remains high. The impact of pre-HSCT oral health factors on the incidence and severity of complications post-HSCT is poorly understood. The aim of this prospective, observational study was to analyze oral health in patients planned for HSCT. Patients ≥18 years requiring HSCT were included from five sites between 2011–2018. General health, oral findings and patient-reported symptoms were registered in 272 patients. Oral symptoms around disease onset were reported by 43 patients (15.9%) and 153 patients (58.8%) reported oral complications during previous chemotherapy. One third of patients experienced oral symptoms at the oral examination before conditioning regimen and HSCT. In total, 124 (46.1%) patients had dental caries, 63 (29.0%) had ≥one tooth with deep periodontal pockets, 147 (75.0%) had ≥one tooth with bleeding on probing. Apical periodontitis was observed in almost 1/4 and partially impacted teeth in 17 (6.3%) patients. Oral mucosal lesions were observed in 84 patients (30.9%). A total of 45 (17.4%) of 259 patients had at least one acute issue to be managed prior to HSCT.symptoms and manifestations of oral disease were prevalent in patients planned for HSCT. The extent of oral and acute dental diseases calls for general oral screening of patients pre-HSCT.
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U2 - https://doi.org/10.1371/journal.pone.0285615
DO - https://doi.org/10.1371/journal.pone.0285615
M3 - Article
C2 - 37200298
SN - 1932-6203
VL - 18
SP - 1
EP - 18
JO - PLOS ONE
JF - PLOS ONE
IS - 5 May
M1 - e0285615
ER -
