Orthopaedic device-related infection: current and future interventions for improved prevention and treatment

T. Fintan Moriarty; Richard Kuehl; Tom Coenye; Willem-Jan Metsemakers; Mario Morgenstern; Edward M. Schwarz; Martijn Riool; Sebastiaan A. J. Zaat; Nina Khana; Stephen L. Kates; R. Geoff Richards

doi:https://doi.org/10.1302/2058-5241.1.000037

Orthopaedic device-related infection: current and future interventions for improved prevention and treatment

T. Fintan Moriarty, Richard Kuehl, Tom Coenye, Willem-Jan Metsemakers, Mario Morgenstern, Edward M. Schwarz, Martijn Riool, Sebastiaan A. J. Zaat, Nina Khana, Stephen L. Kates, R. Geoff Richards

Medical Microbiology and Infection Prevention (AMC)

Research output: Contribution to journal › Article › Academic › peer-review

131 Citations (Scopus)

Abstract

Orthopaedic and trauma device-related infection (ODRI) remains one of the major complications in modern trauma and orthopaedic surgery.Despite best practice in medical and surgical management, neither prophylaxis nor treatment of ODRI is effective in all cases, leading to infections that negatively impact clinical outcome and significantly increase healthcare expenditure.The following review summarises the microbiological profile of modern ODRI, the impact antibiotic resistance has on treatment outcomes, and some of the principles and weaknesses of the current systemic and local antibiotic delivery strategies.The emerging novel strategies aimed at preventing or treating ODRI will be reviewed. Particular attention will be paid to the potential for clinical impact in the coming decades, when such interventions are likely to be critically important.The review focuses on this problem from an interdisciplinary perspective, including basic science innovations and best practice in infectious disease. Cite this article: Moriarty TF, Kuehl R, Coenye T, et al. Orthopaedic device related infection: current and future interventions for improved prevention and treatment. EFORT Open Rev 2016;1:89-99. DOI: 10.1302/2058-5241.1.000037

Original language	English
Pages (from-to)	89-99
Journal	EFORT Open Reviews
Volume	1
Issue number	4
DOIs	https://doi.org/10.1302/2058-5241.1.000037
Publication status	Published - 2016

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https://doi.org/10.1302/2058-5241.1.000037

Cite this

@article{315a1b6cda7e4033a23ade33b143b886,

title = "Orthopaedic device-related infection: current and future interventions for improved prevention and treatment",

abstract = "Orthopaedic and trauma device-related infection (ODRI) remains one of the major complications in modern trauma and orthopaedic surgery.Despite best practice in medical and surgical management, neither prophylaxis nor treatment of ODRI is effective in all cases, leading to infections that negatively impact clinical outcome and significantly increase healthcare expenditure.The following review summarises the microbiological profile of modern ODRI, the impact antibiotic resistance has on treatment outcomes, and some of the principles and weaknesses of the current systemic and local antibiotic delivery strategies.The emerging novel strategies aimed at preventing or treating ODRI will be reviewed. Particular attention will be paid to the potential for clinical impact in the coming decades, when such interventions are likely to be critically important.The review focuses on this problem from an interdisciplinary perspective, including basic science innovations and best practice in infectious disease. Cite this article: Moriarty TF, Kuehl R, Coenye T, et al. Orthopaedic device related infection: current and future interventions for improved prevention and treatment. EFORT Open Rev 2016;1:89-99. DOI: 10.1302/2058-5241.1.000037",

author = "Moriarty, {T. Fintan} and Richard Kuehl and Tom Coenye and Willem-Jan Metsemakers and Mario Morgenstern and Schwarz, {Edward M.} and Martijn Riool and Zaat, {Sebastiaan A. J.} and Nina Khana and Kates, {Stephen L.} and Richards, {R. Geoff}",

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AU - Morgenstern, Mario

AU - Schwarz, Edward M.

AU - Riool, Martijn

AU - Zaat, Sebastiaan A. J.

AU - Khana, Nina

AU - Kates, Stephen L.

AU - Richards, R. Geoff

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