Outbreak of meningococcal disease caused by PorA-deficient meningococci

A. van der Ende; C.T.P. Hopman; W.C.M. Keijzers; L. Spanjaard; E.B. Lodder; P.H.J. van Keulen; J. Dankert

doi:https://doi.org/10.1086/367899

Outbreak of meningococcal disease caused by PorA-deficient meningococci

A. van der Ende, C.T.P. Hopman, W.C.M. Keijzers, L. Spanjaard, E.B. Lodder, P.H.J. van Keulen, J. Dankert

Research output: Contribution to journal › Article › Academic › peer-review

26 Citations (Scopus)

Abstract

An outbreak of 7 cases of group C meningococcal disease occurred during the last week of July and the first week of August 2001 in the southwestern part of The Netherlands. Characterization of the 7 patients' isolates by various typing methods showed that the isolates were identical, except for the expression of PorA. Isolates from 5 patients were PorA deficient. These results show that transmission of PorA-deficient meningococci occurs and that PorA-deficient meningococci can cause invasive disease. PorA-based meningococcal vaccines may provide limited protection

Original language	Undefined/Unknown
Pages (from-to)	869-871
Journal	The Journal of Infectious Diseases
Volume	187
Issue number	5
DOIs	https://doi.org/10.1086/367899
Publication status	Published - 2003

Keywords

AMC wi-eigen

Access to Document

https://doi.org/10.1086/367899

https://pure.uva.nl/ws/files/3413855/33203_142777y.pdf

Cite this

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title = "Outbreak of meningococcal disease caused by PorA-deficient meningococci",

abstract = "An outbreak of 7 cases of group C meningococcal disease occurred during the last week of July and the first week of August 2001 in the southwestern part of The Netherlands. Characterization of the 7 patients' isolates by various typing methods showed that the isolates were identical, except for the expression of PorA. Isolates from 5 patients were PorA deficient. These results show that transmission of PorA-deficient meningococci occurs and that PorA-deficient meningococci can cause invasive disease. PorA-based meningococcal vaccines may provide limited protection",

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author = "{van der Ende}, A. and C.T.P. Hopman and W.C.M. Keijzers and L. Spanjaard and E.B. Lodder and {van Keulen}, P.H.J. and J. Dankert",

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T1 - Outbreak of meningococcal disease caused by PorA-deficient meningococci

AU - van der Ende, A.

AU - Hopman, C.T.P.

AU - Keijzers, W.C.M.

AU - Spanjaard, L.

AU - Lodder, E.B.

AU - van Keulen, P.H.J.

AU - Dankert, J.

PY - 2003

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N2 - An outbreak of 7 cases of group C meningococcal disease occurred during the last week of July and the first week of August 2001 in the southwestern part of The Netherlands. Characterization of the 7 patients' isolates by various typing methods showed that the isolates were identical, except for the expression of PorA. Isolates from 5 patients were PorA deficient. These results show that transmission of PorA-deficient meningococci occurs and that PorA-deficient meningococci can cause invasive disease. PorA-based meningococcal vaccines may provide limited protection

AB - An outbreak of 7 cases of group C meningococcal disease occurred during the last week of July and the first week of August 2001 in the southwestern part of The Netherlands. Characterization of the 7 patients' isolates by various typing methods showed that the isolates were identical, except for the expression of PorA. Isolates from 5 patients were PorA deficient. These results show that transmission of PorA-deficient meningococci occurs and that PorA-deficient meningococci can cause invasive disease. PorA-based meningococcal vaccines may provide limited protection

KW - AMC wi-eigen

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DO - https://doi.org/10.1086/367899

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VL - 187

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JO - The Journal of Infectious Diseases

JF - The Journal of Infectious Diseases

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