TY - JOUR
T1 - Outcome after mitral valve repair for acute and healed infective endocarditis
AU - Feringa, Harm H.H.
AU - Bax, Jeroen J.
AU - Klein, Patrick
AU - Klautz, Robert J.M.
AU - Braun, Jerry
AU - Van Der Wall, Ernst E.
AU - Poldermans, Don
AU - Dion, Robert A.E.
PY - 2006/3
Y1 - 2006/3
N2 - Objective: To evaluate the long-term clinical and echocardiographic outcomes after mitral valve surgery for acute and healed infective endocarditis. Methods: Of 37 consecutive patients presenting with native mitral valve endocarditis, mitral valve repair (MVRep) was feasible in 34 (92%) patients. In 17 (50%) patients, surgery was indicated during antibiotic therapy (acute endocarditis), whereas 17 (50%) underwent surgery after antibiotic therapy was completed (healed endocarditis). Patients were evaluated for early and long-term clinical and echocardiographic outcome. Results: In-hospital death occurred in two (6%) patients and two (6%) died during follow-up, with a 2-year survival of 100% in healed endocarditis as compared to 76% (p = 0.03) in patients undergoing surgery in acute endocarditis. No patient with acute endocarditis needed repeat mitral valve surgery. Three (9%) patients underwent re-operation because of early mitral regurgitation (n = 1) or late recurrent endocarditis (n = 2). The average grade of mitral regurgitation was 3.8 ± 0.4 (all grades 3 to 4+) before surgery and 0.6 ± 0.8 during follow-up (p < 0.001). Significant reductions in left atrial (from 52 ± 8 mm to 46 ± 8 mm, p = 0.004), left ventricular end-diastolic (from 61 ± 8 mm to 54 ± 8 mm, p = 0.001), and end-systolic dimensions (from 41 ± 8 mm to 36 ± 9 mm, p = 0.02) were observed during follow-up, compared to preoperative dimensions. Of note, significant reverse remodeling was only observed in patients undergoing surgery in healed endocarditis. Conclusion: MVRep for mitral valve endocarditis is feasible with good clinical results, maintained valve competency with significant reductions in left atrial and left ventricular dimensions after surgery.
AB - Objective: To evaluate the long-term clinical and echocardiographic outcomes after mitral valve surgery for acute and healed infective endocarditis. Methods: Of 37 consecutive patients presenting with native mitral valve endocarditis, mitral valve repair (MVRep) was feasible in 34 (92%) patients. In 17 (50%) patients, surgery was indicated during antibiotic therapy (acute endocarditis), whereas 17 (50%) underwent surgery after antibiotic therapy was completed (healed endocarditis). Patients were evaluated for early and long-term clinical and echocardiographic outcome. Results: In-hospital death occurred in two (6%) patients and two (6%) died during follow-up, with a 2-year survival of 100% in healed endocarditis as compared to 76% (p = 0.03) in patients undergoing surgery in acute endocarditis. No patient with acute endocarditis needed repeat mitral valve surgery. Three (9%) patients underwent re-operation because of early mitral regurgitation (n = 1) or late recurrent endocarditis (n = 2). The average grade of mitral regurgitation was 3.8 ± 0.4 (all grades 3 to 4+) before surgery and 0.6 ± 0.8 during follow-up (p < 0.001). Significant reductions in left atrial (from 52 ± 8 mm to 46 ± 8 mm, p = 0.004), left ventricular end-diastolic (from 61 ± 8 mm to 54 ± 8 mm, p = 0.001), and end-systolic dimensions (from 41 ± 8 mm to 36 ± 9 mm, p = 0.02) were observed during follow-up, compared to preoperative dimensions. Of note, significant reverse remodeling was only observed in patients undergoing surgery in healed endocarditis. Conclusion: MVRep for mitral valve endocarditis is feasible with good clinical results, maintained valve competency with significant reductions in left atrial and left ventricular dimensions after surgery.
KW - Echocardiography
KW - Infective endocarditis
KW - Mitral valve disease
KW - Mitral valve repair
KW - Mitral valve replacement
KW - Prognosis
UR - http://www.scopus.com/inward/record.url?scp=32144454594&partnerID=8YFLogxK
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=32144454594&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/16423532
U2 - https://doi.org/10.1016/j.ejcts.2005.12.006
DO - https://doi.org/10.1016/j.ejcts.2005.12.006
M3 - Article
C2 - 16423532
SN - 1010-7940
VL - 29
SP - 367
EP - 373
JO - European journal of cardio-thoracic surgery
JF - European journal of cardio-thoracic surgery
IS - 3
ER -