Outcomes associated with different vaccines in individuals with bipolar disorder and impact on the current COVID-19 pandemic- a systematic review

Eva Z. Reininghaus, Mirko Manchia, Nina Dalkner, Nina Bonkat, Alessio Squassina, Isabel Hodl, Eduard Vieta, Andreas Reif, Tomas Hajek, Mikael Landén, Christoph U. Correll, Jan Scott, Bruno Etain, Marcella Rietschel, Veerle Bergink, Monica Martinez-Cengotitabengoa, Lars Vedel Kessing, Andrea Fagiolini, Michael Bauer, Guy GoodwinAna Gonzalez-Pinto, Ralph W. Kupka, Thomas G. Schulze, Trine V. Lagerberg, Ayşegül Yildiz, Chantal Henry, Gunnar Morken, Phillip Ritter, René Ernst Nieslen, Rasmus W. Licht, Andreas Bechdolf, Ole A. Andreassen, Frederike Tabea Fellendorf

Research output: Contribution to journalReview articleAcademicpeer-review

4 Citations (Scopus)


Bipolar disorder (BD) might be associated with higher infection rates of coronavirus disease (COVID-19) which in turn could result in worsening the clinical course and outcome. This may be due to a high prevalence of somatic comorbidities and an increased risk of delays in and poorer treatment of somatic disease in patients with severe mental illness in general. Vaccination is the most important public health intervention to tackle the ongoing pandemic. We undertook a systematic review regarding the data on vaccinations in individuals with BD. Proportion of prevalence rates, efficacy and specific side effects of vaccinations and in individuals with BD were searched. Results show that only five studies have investigated vaccinations in individuals with BD, which substantially limits the interpretation of overall findings. Studies on antibody production after vaccinations in BD are very limited and results are inconsistent. Also, the evidence-based science on side effects of vaccinations in individuals with BD so far is poor.

Original languageEnglish
Pages (from-to)90-99
Number of pages10
JournalEuropean neuropsychopharmacology
Early online date2021
Publication statusPublished - Jan 2022


  • Bipolar disorder
  • COVID-19
  • Infectious diseases
  • Systematic review
  • Vaccination

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