TY - JOUR
T1 - Oxidative stress and macrophages
T2 - Driving forces behind exacerbations of asthma and chronic obstructive pulmonary disease?
AU - de Groot, Linsey E.S.
AU - van der Veen, T. Anienke
AU - Martinez, Fernando O.
AU - Hamann, Jörg
AU - Lutter, René
AU - Melgert, Barbro N.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Oxidative stress is a common feature of obstructive airway diseases like asthma and chronic obstructive pulmonary disease (COPD). Lung macrophages are key innate immune cells that can generate oxidants and are known to display aberrant polarization patterns and defective phagocytic responses in these diseases. Whether these characteristics are linked in one way or another and whether they contribute to the onset and severity of exacerbations in asthma and COPD remain poorly understood. Insight into oxidative stress, macrophages, and their interactions may be important in fully understanding acute worsening of lung disease. This review therefore highlights the current state of the art regarding the role of oxidative stress and macrophages in exacerbations of asthma and COPD. It shows that oxidative stress can attenuate macrophage function, which may result in impaired responses toward exacerbating triggers and may contribute to exaggerated inflammation in the airways.
AB - Oxidative stress is a common feature of obstructive airway diseases like asthma and chronic obstructive pulmonary disease (COPD). Lung macrophages are key innate immune cells that can generate oxidants and are known to display aberrant polarization patterns and defective phagocytic responses in these diseases. Whether these characteristics are linked in one way or another and whether they contribute to the onset and severity of exacerbations in asthma and COPD remain poorly understood. Insight into oxidative stress, macrophages, and their interactions may be important in fully understanding acute worsening of lung disease. This review therefore highlights the current state of the art regarding the role of oxidative stress and macrophages in exacerbations of asthma and COPD. It shows that oxidative stress can attenuate macrophage function, which may result in impaired responses toward exacerbating triggers and may contribute to exaggerated inflammation in the airways.
KW - Macrophage polarization
KW - Obstructive lung disease
KW - Oxidant and antioxidant
UR - http://www.scopus.com/inward/record.url?scp=85060951919&partnerID=8YFLogxK
U2 - https://doi.org/10.1152/ajplung.00456.2018
DO - https://doi.org/10.1152/ajplung.00456.2018
M3 - Review article
C2 - 30520687
SN - 1040-0605
VL - 316
SP - L369-L384
JO - American Journal of Physiology - Lung Cellular and Molecular Physiology
JF - American Journal of Physiology - Lung Cellular and Molecular Physiology
IS - 2
ER -