Oxygen gradient ektacytometry-derived biomarkers are associated with vaso-occlusive crises and correlate with treatment response in sickle cell disease

Minke A. E. Rab; Celeste K. Kanne; Jennifer Bos; Brigitte A. van Oirschot; Camille Boisson; Maite E. Houwing; Jorn Gerritsma; Erik Teske; Celine Renoux; Jurgen Riedl; Roger E. G. Schutgens; Marije Bartels; Erfan Nur; Philippe Joly; Romain Fort; Marjon H. Cnossen; Richard van Wijk; Philippe Connes; Eduard J. van Beers; Vivien A. Sheehan

doi:https://doi.org/10.1002/ajh.26031

Oxygen gradient ektacytometry-derived biomarkers are associated with vaso-occlusive crises and correlate with treatment response in sickle cell disease

Minke A. E. Rab, Celeste K. Kanne, Jennifer Bos, Brigitte A. van Oirschot, Camille Boisson, Maite E. Houwing, Jorn Gerritsma, Erik Teske, Celine Renoux, Jurgen Riedl, Roger E. G. Schutgens, Marije Bartels, Erfan Nur, Philippe Joly, Romain Fort, Marjon H. Cnossen, Richard van Wijk, Philippe Connes, Eduard J. van Beers, Vivien A. Sheehan

Clinical Haematology (AMC)

Research output: Contribution to journal › Comment/Letter to the editor › Academic

21 Citations (Scopus)

Original language	English
Pages (from-to)	E29-E32
Journal	American journal of hematology
Volume	96
Issue number	1
Early online date	2020
DOIs	https://doi.org/10.1002/ajh.26031
Publication status	Published - Jan 2021

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https://doi.org/10.1002/ajh.26031

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Rab, M. A. E., Kanne, C. K., Bos, J., van Oirschot, B. A., Boisson, C., Houwing, M. E., Gerritsma, J., Teske, E., Renoux, C., Riedl, J., Schutgens, R. E. G., Bartels, M., Nur, E., Joly, P., Fort, R., Cnossen, M. H., van Wijk, R., Connes, P., van Beers, E. J., & Sheehan, V. A. (2021). Oxygen gradient ektacytometry-derived biomarkers are associated with vaso-occlusive crises and correlate with treatment response in sickle cell disease. American journal of hematology, 96(1), E29-E32. https://doi.org/10.1002/ajh.26031

@article{2721384ee13f4b6eaa2c35f576f4017f,

title = "Oxygen gradient ektacytometry-derived biomarkers are associated with vaso-occlusive crises and correlate with treatment response in sickle cell disease",

author = "Rab, {Minke A. E.} and Kanne, {Celeste K.} and Jennifer Bos and {van Oirschot}, {Brigitte A.} and Camille Boisson and Houwing, {Maite E.} and Jorn Gerritsma and Erik Teske and Celine Renoux and Jurgen Riedl and Schutgens, {Roger E. G.} and Marije Bartels and Erfan Nur and Philippe Joly and Romain Fort and Cnossen, {Marjon H.} and {van Wijk}, Richard and Philippe Connes and {van Beers}, {Eduard J.} and Sheehan, {Vivien A.}",

note = "Funding Information: Both M.A.E.R., M.E.H., J.G., E.N., M.H.C., and E.J.v.B. are clinical researchers within the Sickle Cell Outcome Research (SCORE) consortium, a multicenter clinical research collaboration in the Netherlands, which gave input on the work described in this manuscript for which we value highly. This research has been funded in part by Eurostars grant estar18105 and by an unrestricted grant provided by RR Mechatronics. This work is also funded by K08 grant from the National Institute of Diabetes and Digestive and Kidney Diseases, and by support from the Department of Pediatrics, Baylor College of Medicine. Funding Information: M.A.E.R., J.B., and B.A.vO. received grant funding from RR Mechatronics. R.v.W. received grant funding from Agios Pharmaceuticals Inc and RR Mechatronics. E.J.v.B. received grant funding Agios Pharmaceuticals Inc, RR Mechatronics, Novartis and Pfizer for investigator initiated research projects. V.A.S. received grant funding from Global Blood Therapeutics, Emmaus, and Novartis for investigator initiated research projects. Funding Information: The authors would like to thank all patients that donated blood for this study. The authors also thank the technicians of the Central Diagnostic Laboratory, Specialized Hematology, University Medical Center Utrecht. As well as the clinical research coordinators of the department of pediatric hematology at the Erasmus Medical Center Rotterdam and the department of hematology at the Amsterdam University Medical Centers. Both M.A.E.R., M.E.H., J.G., E.N., M.H.C., and E.J.v.B. are clinical researchers within the Sickle Cell Outcome Research (SCORE) consortium, a multicenter clinical research collaboration in the Netherlands, which gave input on the work described in this manuscript for which we value highly. This research has been funded in part by Eurostars grant estar18105 and by an unrestricted grant provided by RR Mechatronics. This work is also funded by K08 grant from the National Institute of Diabetes and Digestive and Kidney Diseases, and by support from the Department of Pediatrics, Baylor College of Medicine.",

year = "2021",

month = jan,

doi = "https://doi.org/10.1002/ajh.26031",

language = "English",

volume = "96",

pages = "E29--E32",

journal = "American journal of hematology",

issn = "0361-8609",

publisher = "Wiley-Liss Inc.",

number = "1",

}

Rab, MAE, Kanne, CK, Bos, J, van Oirschot, BA, Boisson, C, Houwing, ME, Gerritsma, J, Teske, E, Renoux, C, Riedl, J, Schutgens, REG, Bartels, M, Nur, E, Joly, P, Fort, R, Cnossen, MH, van Wijk, R, Connes, P, van Beers, EJ & Sheehan, VA 2021, 'Oxygen gradient ektacytometry-derived biomarkers are associated with vaso-occlusive crises and correlate with treatment response in sickle cell disease', American journal of hematology, vol. 96, no. 1, pp. E29-E32. https://doi.org/10.1002/ajh.26031

Oxygen gradient ektacytometry-derived biomarkers are associated with vaso-occlusive crises and correlate with treatment response in sickle cell disease. / Rab, Minke A. E.; Kanne, Celeste K.; Bos, Jennifer et al.
In: American journal of hematology, Vol. 96, No. 1, 01.2021, p. E29-E32.

Research output: Contribution to journal › Comment/Letter to the editor › Academic

TY - JOUR

T1 - Oxygen gradient ektacytometry-derived biomarkers are associated with vaso-occlusive crises and correlate with treatment response in sickle cell disease

AU - Rab, Minke A. E.

AU - Kanne, Celeste K.

AU - Bos, Jennifer

AU - van Oirschot, Brigitte A.

AU - Boisson, Camille

AU - Houwing, Maite E.

AU - Gerritsma, Jorn

AU - Teske, Erik

AU - Renoux, Celine

AU - Riedl, Jurgen

AU - Schutgens, Roger E. G.

AU - Bartels, Marije

AU - Nur, Erfan

AU - Joly, Philippe

AU - Fort, Romain

AU - Cnossen, Marjon H.

AU - van Wijk, Richard

AU - Connes, Philippe

AU - van Beers, Eduard J.

AU - Sheehan, Vivien A.

N1 - Funding Information: Both M.A.E.R., M.E.H., J.G., E.N., M.H.C., and E.J.v.B. are clinical researchers within the Sickle Cell Outcome Research (SCORE) consortium, a multicenter clinical research collaboration in the Netherlands, which gave input on the work described in this manuscript for which we value highly. This research has been funded in part by Eurostars grant estar18105 and by an unrestricted grant provided by RR Mechatronics. This work is also funded by K08 grant from the National Institute of Diabetes and Digestive and Kidney Diseases, and by support from the Department of Pediatrics, Baylor College of Medicine. Funding Information: M.A.E.R., J.B., and B.A.vO. received grant funding from RR Mechatronics. R.v.W. received grant funding from Agios Pharmaceuticals Inc and RR Mechatronics. E.J.v.B. received grant funding Agios Pharmaceuticals Inc, RR Mechatronics, Novartis and Pfizer for investigator initiated research projects. V.A.S. received grant funding from Global Blood Therapeutics, Emmaus, and Novartis for investigator initiated research projects. Funding Information: The authors would like to thank all patients that donated blood for this study. The authors also thank the technicians of the Central Diagnostic Laboratory, Specialized Hematology, University Medical Center Utrecht. As well as the clinical research coordinators of the department of pediatric hematology at the Erasmus Medical Center Rotterdam and the department of hematology at the Amsterdam University Medical Centers. Both M.A.E.R., M.E.H., J.G., E.N., M.H.C., and E.J.v.B. are clinical researchers within the Sickle Cell Outcome Research (SCORE) consortium, a multicenter clinical research collaboration in the Netherlands, which gave input on the work described in this manuscript for which we value highly. This research has been funded in part by Eurostars grant estar18105 and by an unrestricted grant provided by RR Mechatronics. This work is also funded by K08 grant from the National Institute of Diabetes and Digestive and Kidney Diseases, and by support from the Department of Pediatrics, Baylor College of Medicine.

PY - 2021/1

Y1 - 2021/1

UR - http://www.scopus.com/inward/record.url?scp=85096711024&partnerID=8YFLogxK

U2 - https://doi.org/10.1002/ajh.26031

DO - https://doi.org/10.1002/ajh.26031

M3 - Comment/Letter to the editor

C2 - 33095451

SN - 0361-8609

VL - 96

SP - E29-E32

JO - American journal of hematology

JF - American journal of hematology

IS - 1

ER -

Oxygen gradient ektacytometry-derived biomarkers are associated with vaso-occlusive crises and correlate with treatment response in sickle cell disease

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