TY - JOUR
T1 - Oxygen, the lung and the diver: friends and foes?
AU - van Ooij, Pieter-Jan A. M.
AU - Sterk, Peter J.
AU - van Hulst, Robert A.
PY - 2016
Y1 - 2016
N2 - Worldwide, the number of professional and sports divers is increasing. Most of them breathe diving gases with a raised partial pressure of oxygen (PO2). However, if the PO2 is between 50 and 300 kPa (375-2250 mmHg) (hyperoxia), pathological pulmonary changes can develop, known as pulmonary oxygen toxicity (POT). Although in its acute phase, POT is reversible, it can ultimately lead to non-reversible pathological changes. Therefore, it is important to monitor these divers to prevent them from sustaining irreversible lesions. This review summarises the pulmonary pathophysiological effects when breathing oxygen with a PO2 of 50-300 kPa (375-2250 mmHg). We describe the role and the limitations of lung function testing in monitoring the onset and development of POT, and discuss new techniques in respiratory medicine as potential markers in the early development of POT in divers
AB - Worldwide, the number of professional and sports divers is increasing. Most of them breathe diving gases with a raised partial pressure of oxygen (PO2). However, if the PO2 is between 50 and 300 kPa (375-2250 mmHg) (hyperoxia), pathological pulmonary changes can develop, known as pulmonary oxygen toxicity (POT). Although in its acute phase, POT is reversible, it can ultimately lead to non-reversible pathological changes. Therefore, it is important to monitor these divers to prevent them from sustaining irreversible lesions. This review summarises the pulmonary pathophysiological effects when breathing oxygen with a PO2 of 50-300 kPa (375-2250 mmHg). We describe the role and the limitations of lung function testing in monitoring the onset and development of POT, and discuss new techniques in respiratory medicine as potential markers in the early development of POT in divers
U2 - https://doi.org/10.1183/16000617.0049-2016
DO - https://doi.org/10.1183/16000617.0049-2016
M3 - Article
C2 - 27903670
SN - 0905-9180
VL - 25
SP - 496
EP - 505
JO - European Respiratory Review
JF - European Respiratory Review
IS - 142
ER -