P53 and CD44 as clinical markers of tumour progression in colorectal carcinogenesis

J.W.R. Mulder; V.J.M. Wielenga; S.T. Pals; G.J.A. Offerhaus

doi:https://doi.org/10.1023/A:1026403404652

P53 and CD44 as clinical markers of tumour progression in colorectal carcinogenesis

J.W.R. Mulder, V.J.M. Wielenga, S.T. Pals, G.J.A. Offerhaus

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Research output: Contribution to journal › Article › Academic › peer-review

22 Citations (Scopus)

Abstract

Recent advances in molecular genetics have importantly improved our understanding of the development of colorectal cancer. The present review gives an overview of the clinical value of the tumour-suppressor gene, p53, and the CD44 cell adhesion molecule in colorectal cancer and the pitfalls encountered in the immunohistochemical detection of these proteins. Immunohistochemistry potentially forms a procedure applicable for routine diagnosis and prognostication. Therefore, p53 expression and the independent prognostic importance of CD44v6 expression is given particular emphasis, and other molecular events underlying colorectal carcinogenesis are only mentioned briefly

Original language	Undefined/Unknown
Pages (from-to)	439-452
Journal	Histochemical journal
Volume	29
Issue number	6
DOIs	https://doi.org/10.1023/A:1026403404652
Publication status	Published - 1997

Keywords

AMC wi-co

Access to Document

https://doi.org/10.1023/A:1026403404652

https://pure.uva.nl/ws/files/3862626/3162_29544y.pdf

Cite this

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AU - Offerhaus, G.J.A.

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