TY - JOUR
T1 - Pancreatic resection in the pediatric, adolescent and young adult population: nationwide analysis on complications
AU - Pranger, Bobby K.
AU - van Dam, Jacob L.
AU - Groen, Jesse V.
AU - van Eijck, Casper H.
AU - Koerkamp, Bas G.
AU - Bonsing, Bert A.
AU - Mieog, J. Sven D.
AU - Besselink, Marc G.
AU - Busch, Olivier R.
AU - Kazemier, Geert
AU - de Jong, Koert P.
AU - de Kleine, Ruben H. J.
AU - Molenaar, I. Quintus
AU - Stommel, Martijn W. J.
AU - Gerhards, Michael F.
AU - Coolsen, Marielle M. E.
AU - van Santvoort, Hjalmar C.
AU - van der Harst, Erwin
AU - Dutch Pancreatic Cancer Group
AU - Klaase, Joost M.
AU - de Meijer, Vincent E.
N1 - Funding Information: PubMed collaborator: G.P. van der Schelling, MD, PhD (Department of Surgery, Amphia Hospital, Breda, the Netherlands). Publisher Copyright: © 2021 The Authors
PY - 2021/8
Y1 - 2021/8
N2 - Background: The aim of this study was to determine pancreatic surgery specific short- and long-term complications of pediatric, adolescent and young adult (PAYA) patients who underwent pancreatic resection, as compared to a comparator cohort of adults. Methods: A nationwide retrospective cohort study was performed in PAYA patients who underwent pancreatic resection between 2007 and 2016. PAYA was defined as all patients <40 years at time of surgery. Pancreatic surgery-specific complications were assessed according to international definitions and textbook outcome was determined. Results: A total of 230 patients were included in the PAYA cohort (112 distal pancreatectomies, 99 pancreatoduodenectomies), and 2526 patients in the comparator cohort. For pancreatoduodenectomy, severe morbidity (29.3% vs. 28.6%; P = 0.881), in-hospital mortality (1% vs. 4%; P = 0.179) and textbook outcome (62% vs. 58%; P = 0.572) were comparable between the PAYA and the comparator cohort. These outcomes were also similar for distal pancreatectomy. After pancreatoduodenectomy, new-onset diabetes mellitus (8% vs. 16%) and exocrine pancreatic insufficiency (27% vs. 73%) were lower in the PAYA cohort when compared to adult literature. Conclusion: Pancreatic surgery-specific complications were comparable with patients ≥40 years. Development of endocrine and exocrine insufficiency in PAYA patients who underwent pancreatoduodenectomy, however, was substantially lower compared to adult literature.
AB - Background: The aim of this study was to determine pancreatic surgery specific short- and long-term complications of pediatric, adolescent and young adult (PAYA) patients who underwent pancreatic resection, as compared to a comparator cohort of adults. Methods: A nationwide retrospective cohort study was performed in PAYA patients who underwent pancreatic resection between 2007 and 2016. PAYA was defined as all patients <40 years at time of surgery. Pancreatic surgery-specific complications were assessed according to international definitions and textbook outcome was determined. Results: A total of 230 patients were included in the PAYA cohort (112 distal pancreatectomies, 99 pancreatoduodenectomies), and 2526 patients in the comparator cohort. For pancreatoduodenectomy, severe morbidity (29.3% vs. 28.6%; P = 0.881), in-hospital mortality (1% vs. 4%; P = 0.179) and textbook outcome (62% vs. 58%; P = 0.572) were comparable between the PAYA and the comparator cohort. These outcomes were also similar for distal pancreatectomy. After pancreatoduodenectomy, new-onset diabetes mellitus (8% vs. 16%) and exocrine pancreatic insufficiency (27% vs. 73%) were lower in the PAYA cohort when compared to adult literature. Conclusion: Pancreatic surgery-specific complications were comparable with patients ≥40 years. Development of endocrine and exocrine insufficiency in PAYA patients who underwent pancreatoduodenectomy, however, was substantially lower compared to adult literature.
UR - http://www.scopus.com/inward/record.url?scp=85097253979&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.hpb.2020.10.029
DO - https://doi.org/10.1016/j.hpb.2020.10.029
M3 - Article
C2 - 33281080
SN - 1365-182X
VL - 23
SP - 1175
EP - 1184
JO - HPB: The official journal of the International Hepato Pancreato Biliary Association
JF - HPB: The official journal of the International Hepato Pancreato Biliary Association
IS - 8
ER -