TY - JOUR
T1 - Pancytopenia and Hypothyroidism in a Patient with Leukemic Infiltration of the Thyroid as the First Presentation of Acute Lymphoblastic Leukemia
AU - Mooij, Christiaan F.
AU - van Alfen-van der Velden, Janiëlle A. E. M.
AU - Netea-Maier, Romana T.
AU - ten Broek, Roel
AU - Gotthardt, Martin
AU - Hagleitner, Melanie M.
PY - 2018
Y1 - 2018
N2 - We report the case of a 16-year-old female patient with hypothyroidism, goiter, and pancytopenia. Biopsy of the thyroid showed leukemic infiltration. After confirmation of the diagnosis of B-lymphoblastic leukemia, treatment was started. Histologic follow-up at day 33 and 79 showed no residual signs of leukemic infiltration. Hypothyroidism persisted despite successful antileukemic treatment. Leukemic infiltration of the thyroid should be considered as a differential diagnosis in patients with hypothyroidism, goiter, and pancytopenia. We suggest that follow-up of thyroid function and histology should be incorporated in the follow-up of rare patients with acute lymphoblastic leukemia with thyroid infiltration.
AB - We report the case of a 16-year-old female patient with hypothyroidism, goiter, and pancytopenia. Biopsy of the thyroid showed leukemic infiltration. After confirmation of the diagnosis of B-lymphoblastic leukemia, treatment was started. Histologic follow-up at day 33 and 79 showed no residual signs of leukemic infiltration. Hypothyroidism persisted despite successful antileukemic treatment. Leukemic infiltration of the thyroid should be considered as a differential diagnosis in patients with hypothyroidism, goiter, and pancytopenia. We suggest that follow-up of thyroid function and histology should be incorporated in the follow-up of rare patients with acute lymphoblastic leukemia with thyroid infiltration.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85020106136&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/28562510
U2 - https://doi.org/10.1097/MPH.0000000000000869
DO - https://doi.org/10.1097/MPH.0000000000000869
M3 - Article
C2 - 28562510
SN - 1077-4114
VL - 40
SP - 145
EP - 147
JO - Journal of Pediatric Hematology / Oncology
JF - Journal of Pediatric Hematology / Oncology
IS - 2
ER -