Pancytopenia and Hypothyroidism in a Patient with Leukemic Infiltration of the Thyroid as the First Presentation of Acute Lymphoblastic Leukemia

Christiaan F. Mooij, Janiëlle A. E. M. van Alfen-van der Velden, Romana T. Netea-Maier, Roel ten Broek, Martin Gotthardt, Melanie M. Hagleitner

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2 Citations (Scopus)


We report the case of a 16-year-old female patient with hypothyroidism, goiter, and pancytopenia. Biopsy of the thyroid showed leukemic infiltration. After confirmation of the diagnosis of B-lymphoblastic leukemia, treatment was started. Histologic follow-up at day 33 and 79 showed no residual signs of leukemic infiltration. Hypothyroidism persisted despite successful antileukemic treatment. Leukemic infiltration of the thyroid should be considered as a differential diagnosis in patients with hypothyroidism, goiter, and pancytopenia. We suggest that follow-up of thyroid function and histology should be incorporated in the follow-up of rare patients with acute lymphoblastic leukemia with thyroid infiltration.
Original languageEnglish
Pages (from-to)145-147
JournalJournal of Pediatric Hematology / Oncology
Issue number2
Early online date2017
Publication statusPublished - 2018

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