TY - JOUR
T1 - Parametric methods for [18F]flortaucipir PET
AU - Golla, Sandeep S. V.
AU - Wolters, Emma E.
AU - Timmers, Tessa
AU - Ossenkoppele, Rik
AU - van der Weijden, Chris W. J.
AU - Scheltens, Philip
AU - Schwarte, Lothar
AU - Mintun, Mark A.
AU - Devous Sr, Michael D.
AU - Schuit, Robert C.
AU - Windhorst, Albert D.
AU - Lammertsma, Adriaan A.
AU - Yaqub, Maqsood
AU - van Berckel, Bart N. M.
AU - Boellaard, Ronald
PY - 2020/2/1
Y1 - 2020/2/1
N2 - [18F]Flortaucipir is a PET tau tracer used to visualize tau binding in Alzheimer’s disease (AD) in vivo. The present study evaluated the performance of several methods to obtain parametric images of [18F]flortaucipir. One hundred and thirty minutes dynamic PET scans were performed in 10 AD patients and 10 controls. Parametric images were generated using different linearization and basis function approaches. Regional binding potential (BPND) and volume of distribution (VT) values obtained from the parametric images were compared with corresponding values derived using the reversible two-tissue compartment model (2T4k_VB). Performance of SUVr parametric images was assessed by comparing values with distribution volume ratio (DVR) and SRTM-derived BPND estimates obtained using non-linear regression (NLR). Spectral analysis (SA) (r2= 0.92; slope = 0.99) derived VT correlated well with NLR-derived VT. RPM (r2= 0.95; slope = 0.98) derived BPND correlated well with NLR-derived DVR. Although SUVr80–100 min correlated well with NLR-derived DVR (r2= 0.91; slope = 1.09), bias in SUVr appeared to depend on uptake time and underlying level of specific binding. In conclusion, RPM and SA provide parametric images comparable to the NLR estimates. Individual SUVr values are biased compared with DVR and this bias requires further study in a larger dataset in order to understand its consequences.
AB - [18F]Flortaucipir is a PET tau tracer used to visualize tau binding in Alzheimer’s disease (AD) in vivo. The present study evaluated the performance of several methods to obtain parametric images of [18F]flortaucipir. One hundred and thirty minutes dynamic PET scans were performed in 10 AD patients and 10 controls. Parametric images were generated using different linearization and basis function approaches. Regional binding potential (BPND) and volume of distribution (VT) values obtained from the parametric images were compared with corresponding values derived using the reversible two-tissue compartment model (2T4k_VB). Performance of SUVr parametric images was assessed by comparing values with distribution volume ratio (DVR) and SRTM-derived BPND estimates obtained using non-linear regression (NLR). Spectral analysis (SA) (r2= 0.92; slope = 0.99) derived VT correlated well with NLR-derived VT. RPM (r2= 0.95; slope = 0.98) derived BPND correlated well with NLR-derived DVR. Although SUVr80–100 min correlated well with NLR-derived DVR (r2= 0.91; slope = 1.09), bias in SUVr appeared to depend on uptake time and underlying level of specific binding. In conclusion, RPM and SA provide parametric images comparable to the NLR estimates. Individual SUVr values are biased compared with DVR and this bias requires further study in a larger dataset in order to understand its consequences.
KW - AV-1451
KW - Alzheimer’s disease
KW - [ F]flortaucipir
KW - parametric imaging
KW - tau imaging
UR - http://www.scopus.com/inward/record.url?scp=85060538764&partnerID=8YFLogxK
U2 - https://doi.org/10.1177/0271678X18820765
DO - https://doi.org/10.1177/0271678X18820765
M3 - Article
C2 - 30569813
SN - 0271-678X
VL - 40
SP - 365
EP - 373
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
IS - 2
ER -