Paraneoplastic Gastro-Intestinal Anti-Hu Syndrome in Neuroblastoma

C.A.M. Drukker, H.A. Heij, L.C.D. Wijnaendts, J.I.M.L. Verbeke, G.J.L. Kaspers

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The anti-Hu syndrome is a well-known paraneoplastic syndrome and may be rarely seen in patients with neuroblastoma. However, it is relatively unknown that anti-Hu antibodies can cause gastro-intestinal signs and symptoms. We report on a child with neuroblastoma who presented with gastro-intestinal disturbances as a result of the anti-Hu syndrome and summaries two similar case reports reported in literature. Neuroblastoma patients with gastro-intestinal disturbances, ranging from constipation to a paralytic ileus, might suffer from the gastro-intestinal anti-Hu syndrome. The causative antibodies can be determined to diagnose or exclude this syndrome, and successful treatment is possible
Original languageUndefined/Unknown
Pages (from-to)396-398
JournalPediatric Blood and Cancer
Issue number3
Publication statusPublished - 2009

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