TY - JOUR
T1 - PARP and PD-1/PD-L1 checkpoint inhibition in recurrent or metastatic endometrial cancer
AU - Post, Cathalijne C. B.
AU - Westermann, Anneke M.
AU - Bosse, Tjalling
AU - Creutzberg, Carien L.
AU - Kroep, Judith R.
PY - 2020/8/1
Y1 - 2020/8/1
N2 - The prognosis of recurrent or metastatic endometrial cancer is poor, with five-year survival of only 10–20 %. First-line therapy consists of either platinum-based chemotherapy or hormonal therapy. No standard subsequent-line therapy has been identified. In recent years, significant progress has been made in the knowledge on underlying molecular biology of endometrial cancer and potential targets for therapy have been identified. Targeted therapies as poly (ADP-ribose) polymerase (PARP) inhibitors and immunotherapy as PD-1/PD-L1 checkpoint inhibitors have the potential to be effective against specific subtypes of endometrial cancer. Preclinical studies have shown that combining these agents may result in a synergistic effect. In this review, we focus on the molecular basis of checkpoint inhibition and targeted therapy as PARP inhibition in endometrial cancer and summarize available clinical data, and ongoing and planned clinical trials that investigate these agents as mono- or combination therapies in endometrial cancer and where relevant, other gynecological cancers.
AB - The prognosis of recurrent or metastatic endometrial cancer is poor, with five-year survival of only 10–20 %. First-line therapy consists of either platinum-based chemotherapy or hormonal therapy. No standard subsequent-line therapy has been identified. In recent years, significant progress has been made in the knowledge on underlying molecular biology of endometrial cancer and potential targets for therapy have been identified. Targeted therapies as poly (ADP-ribose) polymerase (PARP) inhibitors and immunotherapy as PD-1/PD-L1 checkpoint inhibitors have the potential to be effective against specific subtypes of endometrial cancer. Preclinical studies have shown that combining these agents may result in a synergistic effect. In this review, we focus on the molecular basis of checkpoint inhibition and targeted therapy as PARP inhibition in endometrial cancer and summarize available clinical data, and ongoing and planned clinical trials that investigate these agents as mono- or combination therapies in endometrial cancer and where relevant, other gynecological cancers.
KW - Endometrial cancer
KW - Immune checkpoint inhibitor
KW - Immunotherapy
KW - PARP
KW - PD-1
KW - PD-L1
KW - Targeted therapy
UR - http://www.scopus.com/inward/record.url?scp=85085605259&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.critrevonc.2020.102973
DO - https://doi.org/10.1016/j.critrevonc.2020.102973
M3 - Review article
C2 - 32497971
SN - 1040-8428
VL - 152
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
M1 - 102973
ER -