Past, current and future protocols for combined modality therapy in childhood medulloblastoma

Patricia Kaaijk; Antoinette Y.N. Schouten-van Meeteren; Ben J. Slotman; Gertjan J.L. Kaspers

doi:https://doi.org/10.1586/14737140.3.1.79

Past, current and future protocols for combined modality therapy in childhood medulloblastoma

Patricia Kaaijk, Antoinette Y.N. Schouten-van Meeteren, Ben J. Slotman, Gertjan J.L. Kaspers

Research output: Contribution to journal › Review article › Academic › peer-review

5 Citations (Scopus)

Abstract

Radiotherapy plays a major role in the management of brain tumors, together with surgical resection and more recently, chemotherapy. Improved efficacy of radiotherapy, ranging from novel techniques of radiotherapy to combination with (new) chemotherapeutic drugs or agents that selectively target tumor cells, are currently being explored and offer some hope for improvement of the prognosis of primary brain tumors. This approach might also enable reducing radiation doses, thereby potentially decreasing the risk of severe late effects in pediatric brain tumor patients. This review will evaluate past, current and future treatment approaches of combined modality therapy in childhood medulloblastoma.

Original language	English
Pages (from-to)	79-90
Number of pages	12
Journal	Expert Review of Anticancer Therapy
Volume	3
Issue number	1
DOIs	https://doi.org/10.1586/14737140.3.1.79
Publication status	Published - Feb 2003

Keywords

Antisense technology
Brain tumor
CCNU
COX-2
Carboplatin
Chemotherapy
Childhood
Cisplatin
Cyclophosphamide
Cytarabine
Eroposide
Farnesyltransferase inhibitors
High-dose chemotherapy
Hydroxyurea
Hypoxia
Ifosfamide
Inhibitors
Medulloblastoma
Methotrexate
Methylprednisone
Nitrogen mustard
Prednisone
Procarbazine
Proto-oncogene
Radiosensitization
Radiotherapy
Reduced craniospinal radiation dose
Targeted therapy
Tyrosine kinase inhibitors
Vincristine

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abstract = "Radiotherapy plays a major role in the management of brain tumors, together with surgical resection and more recently, chemotherapy. Improved efficacy of radiotherapy, ranging from novel techniques of radiotherapy to combination with (new) chemotherapeutic drugs or agents that selectively target tumor cells, are currently being explored and offer some hope for improvement of the prognosis of primary brain tumors. This approach might also enable reducing radiation doses, thereby potentially decreasing the risk of severe late effects in pediatric brain tumor patients. This review will evaluate past, current and future treatment approaches of combined modality therapy in childhood medulloblastoma.",

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author = "Patricia Kaaijk and {Schouten-van Meeteren}, {Antoinette Y.N.} and Slotman, {Ben J.} and Kaspers, {Gertjan J.L.}",

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AU - Slotman, Ben J.

AU - Kaspers, Gertjan J.L.

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KW - Hypoxia

KW - Ifosfamide

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KW - Reduced craniospinal radiation dose

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KW - Tyrosine kinase inhibitors

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ER -

Past, current and future protocols for combined modality therapy in childhood medulloblastoma

Abstract

Keywords

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