Pathobiology of Right Ventricular Failure

Jeroen N. Wessels; Frances S. Handoko-de Man; Harm J. Bogaard

doi:https://doi.org/10.1016/B978-0-12-801238-3.11563-6

Pathobiology of Right Ventricular Failure

Jeroen N. Wessels, Frances S. Handoko-de Man, Harm J. Bogaard

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Abstract

The right ventricle (RV) is built to accommodate a large range in venous return and pump the blood through the pulmonary circulation. Left heart disease and several forms of pulmonary disease may lead to a tremendous increase in RV afterload (pulmonary hypertension). The RV adapts by hypertrophy and increasing contractility. However, when this adaptation falls short, the RV dilates and output declines. An unmet increase in oxygen demand, altered metabolism, fibrosis, neurohormonal dysregulation, inflammation and stiffening of the heart are implicated in the transition to right heart failure. This article describes the complex interplay between all these factors.

Original language	English
Title of host publication	Encyclopedia of Respiratory Medicine, Second Edition
Publisher	Elsevier
Pages	542-551
Volume	3
ISBN (Electronic)	9780081027240
ISBN (Print)	9780081027233
DOIs	https://doi.org/10.1016/B978-0-12-801238-3.11563-6
Publication status	Published - 1 Jan 2021

Publication series

Name	Encyclopedia of Respiratory Medicine, Second Edition

Keywords

Cardiac output
Catheterization
Fibrosis
Heart failure
MRI
Myocardium
Pressure-volume relationship
Pulmonary hypertension
Pulmonary vascular resistance
Right ventricle
Right ventricular dysfunction

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https://doi.org/10.1016/B978-0-12-801238-3.11563-6

http://www.sciencedirect.com/science/article/pii/B9780128012383115636

Cite this

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KW - Catheterization

KW - Fibrosis

KW - Heart failure

KW - MRI

KW - Myocardium

KW - Pressure-volume relationship

KW - Pulmonary hypertension

KW - Pulmonary vascular resistance

KW - Right ventricle

KW - Right ventricular dysfunction

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T3 - Encyclopedia of Respiratory Medicine, Second Edition

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BT - Encyclopedia of Respiratory Medicine, Second Edition

PB - Elsevier

ER -

Pathobiology of Right Ventricular Failure

Abstract

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Keywords

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