Pathobiology of Right Ventricular Failure

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review


The right ventricle (RV) is built to accommodate a large range in venous return and pump the blood through the pulmonary circulation. Left heart disease and several forms of pulmonary disease may lead to a tremendous increase in RV afterload (pulmonary hypertension). The RV adapts by hypertrophy and increasing contractility. However, when this adaptation falls short, the RV dilates and output declines. An unmet increase in oxygen demand, altered metabolism, fibrosis, neurohormonal dysregulation, inflammation and stiffening of the heart are implicated in the transition to right heart failure. This article describes the complex interplay between all these factors.
Original languageEnglish
Title of host publicationEncyclopedia of Respiratory Medicine, Second Edition
ISBN (Electronic)9780081027240
ISBN (Print)9780081027233
Publication statusPublished - 1 Jan 2021

Publication series

NameEncyclopedia of Respiratory Medicine, Second Edition


  • Cardiac output
  • Catheterization
  • Fibrosis
  • Heart failure
  • MRI
  • Myocardium
  • Pressure-volume relationship
  • Pulmonary hypertension
  • Pulmonary vascular resistance
  • Right ventricle
  • Right ventricular dysfunction

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