TY - JOUR
T1 - Patient-reported outcomes in axial spondyloarthritis and psoriatic arthritis patients treated with secukinumab for 24 months in daily clinical practice
AU - Christiansen, Sara Nysom
AU - Horskjær Rasmussen, Simon
AU - Pons, Marion
AU - Michelsen, Brigitte
AU - Glintborg, Bente
AU - Gudbjornsson, Bjorn
AU - Grondal, Gerdur
AU - Vencovsky, Jiri
AU - Loft, Anne Gitte
AU - Rotar, Ziga
AU - Pirkmajer, Katja Perdan
AU - Nissen, Michael J.
AU - Baranová, Jana
AU - Macfarlane, Gary J.
AU - Jones, Gareth T.
AU - Iannone, Florenzo
AU - Caporali, Roberto
AU - Laas, Karin
AU - Vorobjov, Sigrid
AU - Giuseppe, Daniela Di
AU - Olofsson, Tor
AU - Provan, Sella Aarrestad
AU - Fagerli, Karen Minde
AU - Castrejon, Isabel
AU - Otero-Varela, Lucia
AU - van de Sande, Marleen
AU - van der Horst-Bruinsma, Irene
AU - Nordström, Dan
AU - Kuusalo, Laura
AU - Bernardes, Miguel
AU - Hetland, Merete Lund
AU - Østergaard, Mikkel
AU - Midtbøll Ørnbjerg, Lykke
N1 - Publisher Copyright: © 2024
PY - 2024/4/1
Y1 - 2024/4/1
N2 - Objectives: In patients with axial spondyloarthritis (axSpA) or psoriatic arthritis (PsA) initiating secukinumab, we aimed to assess and compare the proportion of patients achieving 6-, 12- and 24-month patient-reported outcomes (PRO) remission and the 24-month retention rates. Patients and methods: Patients with axSpA or PsA from 16 European registries, who initiated secukinumab in routine care were included. PRO remission rates were defined as pain, fatigue, Patient Global Assessment (PGA) ≤2 (Numeric Rating Scale (NRS) 0–10) and Health Assessment Questionnaire (HAQ) ≤0.5, for both axSpA and PsA, and were calculated as crude values and adjusted for drug adherence (LUNDEX). Comparisons of axSpA and PsA remission rates were performed using logistic regression analyses (unadjusted and adjusted for multiple confounders). Kaplan-Meier plots with log-rank test and Cox regression analyses were conducted to assess and compare secukinumab retention rates. Results: We included 3087 axSpA and 3246 PsA patients initiating secukinumab. Crude pain, fatigue, PGA and HAQ remission rates were higher in axSpA than in PsA patients, whereas LUNDEX-adjusted remission rates were similar. No differences were found between the patient groups after adjustment for confounders. The 24-month retention rates were similar in axSpA vs. PsA in fully adjusted analyses (HR [95 %CI] = 0.92 [0.84–1.02]). Conclusion: In this large European real-world study of axSpA and PsA patients treated with secukinumab, we demonstrate for the first time a comparable effectiveness in PRO remission and treatment retention rates between these two conditions when adjusted for confounders.
AB - Objectives: In patients with axial spondyloarthritis (axSpA) or psoriatic arthritis (PsA) initiating secukinumab, we aimed to assess and compare the proportion of patients achieving 6-, 12- and 24-month patient-reported outcomes (PRO) remission and the 24-month retention rates. Patients and methods: Patients with axSpA or PsA from 16 European registries, who initiated secukinumab in routine care were included. PRO remission rates were defined as pain, fatigue, Patient Global Assessment (PGA) ≤2 (Numeric Rating Scale (NRS) 0–10) and Health Assessment Questionnaire (HAQ) ≤0.5, for both axSpA and PsA, and were calculated as crude values and adjusted for drug adherence (LUNDEX). Comparisons of axSpA and PsA remission rates were performed using logistic regression analyses (unadjusted and adjusted for multiple confounders). Kaplan-Meier plots with log-rank test and Cox regression analyses were conducted to assess and compare secukinumab retention rates. Results: We included 3087 axSpA and 3246 PsA patients initiating secukinumab. Crude pain, fatigue, PGA and HAQ remission rates were higher in axSpA than in PsA patients, whereas LUNDEX-adjusted remission rates were similar. No differences were found between the patient groups after adjustment for confounders. The 24-month retention rates were similar in axSpA vs. PsA in fully adjusted analyses (HR [95 %CI] = 0.92 [0.84–1.02]). Conclusion: In this large European real-world study of axSpA and PsA patients treated with secukinumab, we demonstrate for the first time a comparable effectiveness in PRO remission and treatment retention rates between these two conditions when adjusted for confounders.
KW - Biologic therapy
KW - Clinical study in epidemiology
KW - Cohort study
KW - Rheumatic diseases
KW - Spondyloarthritis
UR - http://www.scopus.com/inward/record.url?scp=85184021202&partnerID=8YFLogxK
U2 - 10.1016/j.semarthrit.2024.152388
DO - 10.1016/j.semarthrit.2024.152388
M3 - Article
C2 - 38301349
SN - 0049-0172
VL - 65
JO - Seminars in Arthritis and Rheumatism
JF - Seminars in Arthritis and Rheumatism
M1 - 152388
ER -