TY - JOUR
T1 - Patients with diffuse idiopathic skeletal hyperostosis have an increased burden of thoracic aortic calcifications
AU - Harlianto, Netanja I.
AU - Westerink, Jan
AU - Hol, Marjolein E.
AU - Wittenberg, Rianne
AU - Foppen, Wouter
AU - van der Veen, Pieternella H.
AU - van Ginneken, Bram
AU - Verlaan, Jorrit-Jan
AU - de Jong, Pim A.
AU - Mohamed Hoesein, Firdaus A. A.
AU - Asselbergs, F. W.
AU - Nathoe, H. M.
AU - de Borst, G. J.
AU - Bots, M. L.
AU - Geerlings, M. I.
AU - Emmelot, M. H.
AU - de Jong, P. A.
AU - Leiner, T.
AU - Lely, A. T.
AU - van der Kaaij, N. P.
AU - Kappelle, L. J.
AU - Ruigrok, Y. M.
AU - Verhaar, M. C.
AU - Visseren, F. L. J.
N1 - Publisher Copyright: © 2022 The Author(s). Published by Oxford University Press on behalf of the British Society for Rheumatology.
PY - 2022
Y1 - 2022
N2 - Objectives.: DISH has been associated with increased coronary artery calcifications and incident ischaemic stroke. The formation of bone along the spine may share pathways with calcium deposition in the aorta. We hypothesized that patients with DISH have increased vascular calcifications. Therefore we aimed to investigate the presence and extent of DISH in relation to thoracic aortic calcification (TAC) severity. Methods.: This cross-sectional study included 4703 patients from the Second Manifestation of ARTerial disease cohort, consisting of patients with cardiovascular events or risk factors for cardiovascular disease. Chest radiographs were scored for DISH using the Resnick criteria. Different severities of TAC were scored arbitrarily from no TAC to mild, moderate or severe TAC. Using multivariate logistic regression, the associations between DISH and TAC were analysed with adjustments for age, sex, BMI, diabetes, smoking status, non-high-density lipoprotein cholesterol, cholesterol lowering drug usage, renal function and blood pressure. Results.: A total of 442 patients (9.4%) had evidence of DISH and 1789 (38%) patients had TAC. The prevalence of DISH increased from 6.6% in the no TAC group to 10.8% in the mild, 14.3% in the moderate and 17.1% in the severe TAC group. After adjustments, DISH was significantly associated with the presence of TAC [odds ratio (OR) 1.46 [95% CI 1.17, 1.82)]. In multinomial analyses, DISH was associated with moderate TAC [OR 1.43 (95% CI 1.06, 1.93)] and severe TAC [OR 1.67 (95% CI 1.19, 2.36)]. Conclusions.: Subjects with DISH have increased TACs, providing further evidence that patients with DISH have an increased burden of vascular calcifications.
AB - Objectives.: DISH has been associated with increased coronary artery calcifications and incident ischaemic stroke. The formation of bone along the spine may share pathways with calcium deposition in the aorta. We hypothesized that patients with DISH have increased vascular calcifications. Therefore we aimed to investigate the presence and extent of DISH in relation to thoracic aortic calcification (TAC) severity. Methods.: This cross-sectional study included 4703 patients from the Second Manifestation of ARTerial disease cohort, consisting of patients with cardiovascular events or risk factors for cardiovascular disease. Chest radiographs were scored for DISH using the Resnick criteria. Different severities of TAC were scored arbitrarily from no TAC to mild, moderate or severe TAC. Using multivariate logistic regression, the associations between DISH and TAC were analysed with adjustments for age, sex, BMI, diabetes, smoking status, non-high-density lipoprotein cholesterol, cholesterol lowering drug usage, renal function and blood pressure. Results.: A total of 442 patients (9.4%) had evidence of DISH and 1789 (38%) patients had TAC. The prevalence of DISH increased from 6.6% in the no TAC group to 10.8% in the mild, 14.3% in the moderate and 17.1% in the severe TAC group. After adjustments, DISH was significantly associated with the presence of TAC [odds ratio (OR) 1.46 [95% CI 1.17, 1.82)]. In multinomial analyses, DISH was associated with moderate TAC [OR 1.43 (95% CI 1.06, 1.93)] and severe TAC [OR 1.67 (95% CI 1.19, 2.36)]. Conclusions.: Subjects with DISH have increased TACs, providing further evidence that patients with DISH have an increased burden of vascular calcifications.
KW - atherosclerosis
KW - bone formation
KW - calcification
KW - diffuse idiopathic skeletal hyperostosis
KW - thoracic aortic calcification
UR - http://www.scopus.com/inward/record.url?scp=85141335565&partnerID=8YFLogxK
U2 - https://doi.org/10.1093/rap/rkac060
DO - https://doi.org/10.1093/rap/rkac060
M3 - Article
C2 - 35993014
SN - 2514-1775
VL - 6
JO - Rheumatology Advances in Practice
JF - Rheumatology Advances in Practice
IS - 2
M1 - rkac060
ER -