TY - JOUR
T1 - Patterns of clinical joint inflammation in juvenile idiopathic arthritis
AU - Heckert, Sascha L.
AU - Hissink-Muller, Petra C. E.
AU - van den Berg, J. Merlijn
AU - Schonenberg-Meinema, Dieneke
AU - van Suijlekom-Smit, Lisette W. A.
AU - van Rossum, Marion A. J.
AU - Koopman, Yvonne
AU - ten Cate, Rebecca
AU - Brinkman, Danielle M. C.
AU - Huizinga, Tom W. J.
AU - Allaart, Cornelia F.
AU - Bergstra, Sytske Anne
N1 - Funding Information: The original BeSt for Kids study received financial support from Pfizer. The authors, not the sponsors, were responsible for the study design, the collection, analyses and interpretation of all data, the writing of this article and the decision to publish. Publisher Copyright: © 2023 BMJ Publishing Group. All rights reserved.
PY - 2023/3/16
Y1 - 2023/3/16
N2 - OBJECTIVES: We studied patterns of joint inflammation in juvenile idiopathic arthritis (JIA) to assess whether joint activity recurs locally in the same joints. METHODS: Joints of 91 patients of the BeSt for Kids study, a treat-to-target trial for children with recent-onset oligoarticular, rheumatoid factor-negative polyarticular and psoriatic JIA, were clinically assessed during 2 years (10 study visits). The association between joint inflammation at baseline and later inflammation in the same joint was assessed using a multilevel mixed-effects logistic regression model at joint level. With a Poisson model, the association between baseline joint inflammation and the number of study visits at which the same joint was recurrently inflamed was tested. RESULTS: Of the 6097 joints studied, 15% (897) was clinically inflamed at baseline. In 42% (377/897) of those joints, inflammation recurred during follow-up. Joint inflammation at baseline was statistically significantly associated with joint inflammation during follow-up in the same joint (OR 3.9, 95% CI 3.5 to 4.4) and specifically with the number of episodes of recurrent joint inflammation (IRR 1.6, 95% CI 1.2 to 2.1). CONCLUSION: In JIA, joint inflammation has the tendency to recur multiple times in joints that are clinically inflamed at disease onset. This indicates that local factors might play a role in the processes contributing to the occurrence of JIA flares.
AB - OBJECTIVES: We studied patterns of joint inflammation in juvenile idiopathic arthritis (JIA) to assess whether joint activity recurs locally in the same joints. METHODS: Joints of 91 patients of the BeSt for Kids study, a treat-to-target trial for children with recent-onset oligoarticular, rheumatoid factor-negative polyarticular and psoriatic JIA, were clinically assessed during 2 years (10 study visits). The association between joint inflammation at baseline and later inflammation in the same joint was assessed using a multilevel mixed-effects logistic regression model at joint level. With a Poisson model, the association between baseline joint inflammation and the number of study visits at which the same joint was recurrently inflamed was tested. RESULTS: Of the 6097 joints studied, 15% (897) was clinically inflamed at baseline. In 42% (377/897) of those joints, inflammation recurred during follow-up. Joint inflammation at baseline was statistically significantly associated with joint inflammation during follow-up in the same joint (OR 3.9, 95% CI 3.5 to 4.4) and specifically with the number of episodes of recurrent joint inflammation (IRR 1.6, 95% CI 1.2 to 2.1). CONCLUSION: In JIA, joint inflammation has the tendency to recur multiple times in joints that are clinically inflamed at disease onset. This indicates that local factors might play a role in the processes contributing to the occurrence of JIA flares.
KW - Inflammation
KW - Juvenile Idiopathic Arthritis
KW - Synovitis
UR - http://www.scopus.com/inward/record.url?scp=85150312562&partnerID=8YFLogxK
U2 - https://doi.org/10.1136/rmdopen-2022-002941
DO - https://doi.org/10.1136/rmdopen-2022-002941
M3 - Article
C2 - 36927851
SN - 2056-5933
VL - 9
JO - RMD OPEN
JF - RMD OPEN
IS - 1
M1 - e002941
ER -