Peanut thresholds in peanut-allergic children are related to dietary composition

Daisy Luiten; Maarten Biezeveld; Olga van Doorn; Hanae Riady; Ming Yang; Femke Bergsma; Atie van der Plas; Kim Brand; Nicolette Arends; Annette de Bruin; Jeanne de Vries; Tim de Meij; Berber Vlieg-Boerstra

doi:https://doi.org/10.1002/iid3.841

Peanut thresholds in peanut-allergic children are related to dietary composition

Daisy Luiten, Maarten Biezeveld, Olga van Doorn, Hanae Riady, Ming Yang, Femke Bergsma, Atie van der Plas, Kim Brand, Nicolette Arends, Annette de Bruin, Jeanne de Vries, Tim de Meij, Berber Vlieg-Boerstra

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

Abstract

BACKGROUND: There is no clear explanation for the large variation in threshold levels among peanut-allergic children. We hypothesized that diet composition can partly explain this variation in thresholds, as nutrients and foods influence the intestinal barrier function and microbiota.

AIM: to explore the relationship between the threshold levels for peanut and nutritional intake and gut microbial composition in peanut-allergic children.

METHODS: In this explorative cross-sectional study the cumulative threshold levels for peanut were determined by oral food challenge tests. Data on nutrients and foods consumed were obtained from 3-day food diaries. Microbial composition of faeces and saliva were determined by molecular microbiota detection technique. Multivariable linear regression analysis and multiple logistic regression were used to explore the associations, adjusted for energy and senitization.

RESULTS: Sixty-five children were included, of whom 32 (49%) (median age 50 months, IQR 28.0-96.5) had a positive oral food challenge. Significant positive associations were found between the intake of total carbohydrates, vitamin A and cumulative threshold levels for peanut, while significant negative associations were found for long-chain polyunsaturated fatty acids, linoleic acid and omega-6 fatty acids. No associations were found between threshold levels and microbial composition of faeces and saliva. However, a significant higher abundance of Proteobacteria and Bacteroidetes in saliva (p = 0.011 and 0.04, respectively) and of Proteobacteria in faeces (p = 0.003) were found in children with a positive peanut challenge compared to children with a negative peanut challenge.

CONCLUSION: As a novel concept, this study showed that dietary composition is related to threshold levels for peanut.

Original language	English
Article number	e841
Pages (from-to)	e841
Journal	Immunity, Inflammation and Disease
Volume	11
Issue number	5
DOIs	https://doi.org/10.1002/iid3.841
Publication status	Published - 1 May 2023

Keywords

Humans
Child
Child, Preschool
Arachis
Cross-Sectional Studies
Peanut Hypersensitivity/diagnosis
Diet
Food
Allergens
microbiome
oral food challenge
peanut allergy
thresholds

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https://doi.org/10.1002/iid3.841

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@article{ed6aa44f7787415988ede9ae94451c3c,

title = "Peanut thresholds in peanut-allergic children are related to dietary composition",

abstract = "BACKGROUND: There is no clear explanation for the large variation in threshold levels among peanut-allergic children. We hypothesized that diet composition can partly explain this variation in thresholds, as nutrients and foods influence the intestinal barrier function and microbiota.AIM: to explore the relationship between the threshold levels for peanut and nutritional intake and gut microbial composition in peanut-allergic children.METHODS: In this explorative cross-sectional study the cumulative threshold levels for peanut were determined by oral food challenge tests. Data on nutrients and foods consumed were obtained from 3-day food diaries. Microbial composition of faeces and saliva were determined by molecular microbiota detection technique. Multivariable linear regression analysis and multiple logistic regression were used to explore the associations, adjusted for energy and senitization.RESULTS: Sixty-five children were included, of whom 32 (49%) (median age 50 months, IQR 28.0-96.5) had a positive oral food challenge. Significant positive associations were found between the intake of total carbohydrates, vitamin A and cumulative threshold levels for peanut, while significant negative associations were found for long-chain polyunsaturated fatty acids, linoleic acid and omega-6 fatty acids. No associations were found between threshold levels and microbial composition of faeces and saliva. However, a significant higher abundance of Proteobacteria and Bacteroidetes in saliva (p = 0.011 and 0.04, respectively) and of Proteobacteria in faeces (p = 0.003) were found in children with a positive peanut challenge compared to children with a negative peanut challenge.CONCLUSION: As a novel concept, this study showed that dietary composition is related to threshold levels for peanut.",

keywords = "Humans, Child, Child, Preschool, Arachis, Cross-Sectional Studies, Peanut Hypersensitivity/diagnosis, Diet, Food, Allergens, microbiome, oral food challenge, peanut allergy, thresholds",

author = "Daisy Luiten and Maarten Biezeveld and {van Doorn}, Olga and Hanae Riady and Ming Yang and Femke Bergsma and {van der Plas}, Atie and Kim Brand and Nicolette Arends and {de Bruin}, Annette and {de Vries}, Jeanne and {de Meij}, Tim and Berber Vlieg-Boerstra",

note = "{\textcopyright} 2023 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.",

year = "2023",

month = may,

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doi = "https://doi.org/10.1002/iid3.841",

language = "English",

volume = "11",

pages = "e841",

journal = "Immunity, Inflammation and Disease",

issn = "2050-4527",

publisher = "John Wiley and Sons Ltd",

number = "5",

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T1 - Peanut thresholds in peanut-allergic children are related to dietary composition

AU - Luiten, Daisy

AU - Biezeveld, Maarten

AU - van Doorn, Olga

AU - Riady, Hanae

AU - Yang, Ming

AU - Bergsma, Femke

AU - van der Plas, Atie

AU - Brand, Kim

AU - Arends, Nicolette

AU - de Bruin, Annette

AU - de Vries, Jeanne

AU - de Meij, Tim

AU - Vlieg-Boerstra, Berber

PY - 2023/5/1

Y1 - 2023/5/1

N2 - BACKGROUND: There is no clear explanation for the large variation in threshold levels among peanut-allergic children. We hypothesized that diet composition can partly explain this variation in thresholds, as nutrients and foods influence the intestinal barrier function and microbiota.AIM: to explore the relationship between the threshold levels for peanut and nutritional intake and gut microbial composition in peanut-allergic children.METHODS: In this explorative cross-sectional study the cumulative threshold levels for peanut were determined by oral food challenge tests. Data on nutrients and foods consumed were obtained from 3-day food diaries. Microbial composition of faeces and saliva were determined by molecular microbiota detection technique. Multivariable linear regression analysis and multiple logistic regression were used to explore the associations, adjusted for energy and senitization.RESULTS: Sixty-five children were included, of whom 32 (49%) (median age 50 months, IQR 28.0-96.5) had a positive oral food challenge. Significant positive associations were found between the intake of total carbohydrates, vitamin A and cumulative threshold levels for peanut, while significant negative associations were found for long-chain polyunsaturated fatty acids, linoleic acid and omega-6 fatty acids. No associations were found between threshold levels and microbial composition of faeces and saliva. However, a significant higher abundance of Proteobacteria and Bacteroidetes in saliva (p = 0.011 and 0.04, respectively) and of Proteobacteria in faeces (p = 0.003) were found in children with a positive peanut challenge compared to children with a negative peanut challenge.CONCLUSION: As a novel concept, this study showed that dietary composition is related to threshold levels for peanut.

AB - BACKGROUND: There is no clear explanation for the large variation in threshold levels among peanut-allergic children. We hypothesized that diet composition can partly explain this variation in thresholds, as nutrients and foods influence the intestinal barrier function and microbiota.AIM: to explore the relationship between the threshold levels for peanut and nutritional intake and gut microbial composition in peanut-allergic children.METHODS: In this explorative cross-sectional study the cumulative threshold levels for peanut were determined by oral food challenge tests. Data on nutrients and foods consumed were obtained from 3-day food diaries. Microbial composition of faeces and saliva were determined by molecular microbiota detection technique. Multivariable linear regression analysis and multiple logistic regression were used to explore the associations, adjusted for energy and senitization.RESULTS: Sixty-five children were included, of whom 32 (49%) (median age 50 months, IQR 28.0-96.5) had a positive oral food challenge. Significant positive associations were found between the intake of total carbohydrates, vitamin A and cumulative threshold levels for peanut, while significant negative associations were found for long-chain polyunsaturated fatty acids, linoleic acid and omega-6 fatty acids. No associations were found between threshold levels and microbial composition of faeces and saliva. However, a significant higher abundance of Proteobacteria and Bacteroidetes in saliva (p = 0.011 and 0.04, respectively) and of Proteobacteria in faeces (p = 0.003) were found in children with a positive peanut challenge compared to children with a negative peanut challenge.CONCLUSION: As a novel concept, this study showed that dietary composition is related to threshold levels for peanut.

KW - Humans

KW - Child

KW - Child, Preschool

KW - Arachis

KW - Cross-Sectional Studies

KW - Peanut Hypersensitivity/diagnosis

KW - Diet

KW - Food

KW - Allergens

KW - microbiome

KW - oral food challenge

KW - peanut allergy

KW - thresholds

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U2 - https://doi.org/10.1002/iid3.841

DO - https://doi.org/10.1002/iid3.841

M3 - Article

C2 - 37249298

SN - 2050-4527

VL - 11

SP - e841

JO - Immunity, Inflammation and Disease

JF - Immunity, Inflammation and Disease

IS - 5

M1 - e841

ER -

Peanut thresholds in peanut-allergic children are related to dietary composition

Abstract

Keywords

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