TY - JOUR
T1 - Perfusion angiography of the foot in patients with critical limb ischemia: description of the technique
AU - Jens, Sjoerd
AU - Marquering, Henk A.
AU - Koelemay, Mark J. W.
AU - Reekers, Jim A.
PY - 2015
Y1 - 2015
N2 - To study the feasibility of 2D perfusion imaging in critical limb ischemia (CLI). Perfusion angiography is a new technology which was tested in 18 patients with CLI of the foot. A standardized protocol was used with a catheter placed at the mid-part of the popliteal artery, and a total of 9 cc of non-ionic iodinated contrast material was injected at a rate of 3 cc/sec. The technology is based on early cardiology research where iodinated contrast agents were used for imaging of cardiac perfusion. During the first pass of the contrast, there is a significant diffusion of the contrast agents into the interstitial space, particularly for non-ionic and low-molecular-weight compounds. The original angiography data can be used to make a time-density curve, which represents the actual perfusion of the foot in time. Angiographic perfusion imaging is a post-processing modality for which no extra contrast or radiation is needed. With this technique, it is possible to get more information about the perfusion status and microcirculation of the foot. This is a step toward functional imaging in CLI patients
AB - To study the feasibility of 2D perfusion imaging in critical limb ischemia (CLI). Perfusion angiography is a new technology which was tested in 18 patients with CLI of the foot. A standardized protocol was used with a catheter placed at the mid-part of the popliteal artery, and a total of 9 cc of non-ionic iodinated contrast material was injected at a rate of 3 cc/sec. The technology is based on early cardiology research where iodinated contrast agents were used for imaging of cardiac perfusion. During the first pass of the contrast, there is a significant diffusion of the contrast agents into the interstitial space, particularly for non-ionic and low-molecular-weight compounds. The original angiography data can be used to make a time-density curve, which represents the actual perfusion of the foot in time. Angiographic perfusion imaging is a post-processing modality for which no extra contrast or radiation is needed. With this technique, it is possible to get more information about the perfusion status and microcirculation of the foot. This is a step toward functional imaging in CLI patients
U2 - https://doi.org/10.1007/s00270-014-1036-5
DO - https://doi.org/10.1007/s00270-014-1036-5
M3 - Article
C2 - 25501266
SN - 0174-1551
VL - 38
SP - 201
EP - 205
JO - Cardiovascular and interventional radiology
JF - Cardiovascular and interventional radiology
IS - 1
ER -