TY - JOUR
T1 - Perinatal outcomes in vertically infected neonates during a Chikungunya outbreak on the Island of Curaçao
AU - van Enter, Bert J. D.
AU - Huibers, Minke H. W.
AU - van Rooij, Linda
AU - Steingrover, Radjinkoemar
AU - van Hensbroek, Michael Boele
AU - Voigt, Ralph R.
AU - Hol, Jeroen
PY - 2018
Y1 - 2018
N2 - Recent outbreaks of Chikungunya virus (CHIKV) infection confirm the vulnerability of neonates after vertical transmission. In 2014, CHIKV was reported for the first time in the Americas, including the island of Curaçao. We describe the outcomes of symptomatic neonates with vertically transmitted CHIKV infection during the CHIKV epidemic, who were admitted in the Saint Elisabeth Hospital, Willemstad, Curaçao. There were three symptomatic neonates with serologically confirmed infection. Two neonates developed neurological complications, including convulsions and intracerebral bleeding. One newborn, in whom maternal infection occurred 7 weeks before delivery, had a fatal outcome after birth. Maternal-fetal transmission of CHIKV may cause severe neonatal complications. There is a need to share experiences and to implement protocols toward the management of perinatal CHIKV infection.
AB - Recent outbreaks of Chikungunya virus (CHIKV) infection confirm the vulnerability of neonates after vertical transmission. In 2014, CHIKV was reported for the first time in the Americas, including the island of Curaçao. We describe the outcomes of symptomatic neonates with vertically transmitted CHIKV infection during the CHIKV epidemic, who were admitted in the Saint Elisabeth Hospital, Willemstad, Curaçao. There were three symptomatic neonates with serologically confirmed infection. Two neonates developed neurological complications, including convulsions and intracerebral bleeding. One newborn, in whom maternal infection occurred 7 weeks before delivery, had a fatal outcome after birth. Maternal-fetal transmission of CHIKV may cause severe neonatal complications. There is a need to share experiences and to implement protocols toward the management of perinatal CHIKV infection.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85058150136&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30328407
U2 - https://doi.org/10.4269/ajtmh.17-0957
DO - https://doi.org/10.4269/ajtmh.17-0957
M3 - Article
C2 - 30328407
SN - 0002-9637
VL - 99
SP - 1415
EP - 1418
JO - American journal of tropical medicine and hygiene
JF - American journal of tropical medicine and hygiene
IS - 6
ER -