TY - JOUR
T1 - Perinatal risk indicators for long-term neurological morbidity among preterm neonates
AU - Teune, Margreet J.
AU - van Wassenaer, Aleid G.
AU - van Dommelen, Paula
AU - Mol, Ben Willem J.
AU - Opmeer, Brent C.
AU - AUTHOR GROUP
AU - Buitendijk, S. E.
AU - Lanting, C. I.
AU - Verrips, G. H. W.
AU - van der Pal, K. M.
AU - van Wouwe, J. P.
AU - van der Pal, S. M.
AU - Hille, E. T. M.
AU - Verloove-Vanhorick, S. P.
AU - Kok, J. H.
AU - Ilsen, A.
AU - van der Lans, M.
AU - Boelen-van der Loo, W. J. C.
AU - Lundqvist, T.
AU - Heymans, H. S. A.
AU - Duiverman, E. J.
AU - Geven, W. B.
AU - Duiverman, M. L.
AU - Geven, L. I.
AU - Vrijlandt, E. J. L. E.
AU - Mulder, A. L. M.
AU - Gerver, A.
AU - Kollée, L. A. A.
AU - Reijmers, L.
AU - Sonnemans, R.
AU - Wit, J. M.
AU - Dekker, F. W.
AU - Finken, M. J. J.
AU - Weisglas-Kuperus, N.
AU - Keijzer-Veen, M. G.
AU - van der Heijden, A. J.
AU - van Goudoever, J. B.
AU - van Weissenbruch, M. M.
AU - Cranendonk, A.
AU - Delemarre-van de Waal, H. A.
AU - de Groot, L.
AU - Samsom, J. F.
AU - de Vries, L. S.
AU - Rademaker, K. J.
AU - Moerman, E.
AU - Voogsgeerd, M.
AU - de Kleine, M. J. K.
AU - Andriessen, P.
AU - Dielissen- van Helvoirt, C. C. M.
AU - Mohamed, I.
AU - van Straaten, H. L. M.
PY - 2011
Y1 - 2011
N2 - Many obstetric interventions are performed to improve long-term neonatal outcome. However, long-term neonatal outcome is usually not a primary outcome because it is time-consuming and expensive. The aim of this project was to identify different perinatal risk indicators and to develop prediction models for neurologic morbidity at 2 and 5 years of age. Data from a Dutch cohort study of preterm and small-for-gestational-age infants was used. Neonates who were born in The Netherlands in 1983 with a gestational age of <34 weeks and without congenital abnormalities were included (n = 753). Infants were divided in 3 groups: no handicap, minor handicap, and major handicap. Common risk indicators for major handicaps at 2 and 5 years of age were male sex (odds ratio, 2.7 and 3.0, respectively), seizures after ≥2 days of life (odds ratio, 5.8 and 5.8, respectively), and intracranial hemorrhage (odds ratio, 3.8 and 2.6, respectively). In this cohort, male sex, intracranial hemorrhage, and seizures seem to be important risk indicators for long-term neurologic morbidity
AB - Many obstetric interventions are performed to improve long-term neonatal outcome. However, long-term neonatal outcome is usually not a primary outcome because it is time-consuming and expensive. The aim of this project was to identify different perinatal risk indicators and to develop prediction models for neurologic morbidity at 2 and 5 years of age. Data from a Dutch cohort study of preterm and small-for-gestational-age infants was used. Neonates who were born in The Netherlands in 1983 with a gestational age of <34 weeks and without congenital abnormalities were included (n = 753). Infants were divided in 3 groups: no handicap, minor handicap, and major handicap. Common risk indicators for major handicaps at 2 and 5 years of age were male sex (odds ratio, 2.7 and 3.0, respectively), seizures after ≥2 days of life (odds ratio, 5.8 and 5.8, respectively), and intracranial hemorrhage (odds ratio, 3.8 and 2.6, respectively). In this cohort, male sex, intracranial hemorrhage, and seizures seem to be important risk indicators for long-term neurologic morbidity
U2 - https://doi.org/10.1016/j.ajog.2011.02.055
DO - https://doi.org/10.1016/j.ajog.2011.02.055
M3 - Article
C2 - 21788170
SN - 0002-9378
VL - 204
SP - 396.e1-396.e14
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 5
ER -