TY - JOUR
T1 - Perinatal risk-indicators for long-term respiratory morbidity among preterm or very low birth weight neonates
AU - Teune, Margreet J.
AU - van Wassenaer, Aleid G.
AU - van Buuren, Stef
AU - Mol, Ben Willem J.
AU - Opmeer, Brent C.
AU - AUTHOR GROUP
AU - Buitendijk, S. E.
AU - Lanting, C. I.
AU - Verrips, G. H. W.
AU - van der Pal, K. M.
AU - van Wouwe, J. P.
AU - van der Pal, S. M.
AU - Hille, E. T. M.
AU - Verloove-Vanhorick, S. P.
AU - Kok, J. H.
AU - Ilsen, A.
AU - van der Lans, M.
AU - Boelen-van der Loo, W. J. C.
AU - Lundqvist, T.
AU - Heymans, H. S. A.
AU - Duiverman, E. J.
AU - Geven, W. B.
AU - Duiverman, M. L.
AU - Geven, L. I.
AU - Vrijlandt, E. J. L. E.
AU - Mulder, A. L. M.
AU - Gerver, A.
AU - Kollée, L. A. A.
AU - Reijmers, L.
AU - Sonnemans, R.
AU - Wit, J. M.
AU - Dekker, F. W.
AU - Finken, M. J. J.
AU - Weisglas-Kuperus, N.
AU - Keijzer-Veen, M. G.
AU - van der Heijden, A. J.
AU - van Goudoever, J. B.
AU - van Weissenbruch, M. M.
AU - Cranendonk, A.
AU - Delemarre-van de Waal, H. A.
AU - de Groot, L.
AU - Samsom, J. F.
AU - de Vries, L. S.
AU - Rademaker, K. J.
AU - Moerman, E.
AU - Voogsgeerd, M.
AU - de Kleine, M. J. K.
AU - Andriessen, P.
AU - Dielissen-van Helvoirt, C. C. M.
AU - Mohamed, I.
AU - van Straaten, H. L. M.
PY - 2012
Y1 - 2012
N2 - Objectives: To develop prediction models for long-term respiratory morbidity. To explore if respiratory distress syndrome (RDS) is a risk-indicator for long-term respiratory morbidity and to identify other perinatal risk-indicators for long-term respiratory morbidity. Study design: In the Dutch POPS cohort 1338 live born infants delivered in The Netherlands in 1983, either before 32 completed weeks gestation and/or with a birth weight below 1500 g, were followed prospectively. We used multivariable logistic regression analyses to construct three prediction models for respiratory morbidity at 2, 5 and 19 years of age. Results: At 2 years of age, maternal smoking (adjusted OR 1.5, 95% CI 1.0-2.4), prolonged rupture of membranes (adjusted OR 2.3, 95% CI 1.3-4.1), pre-eclampsia (adjusted OR 1.9, 95% CI 1.1-4.1), male gender (adjusted OR 1.5, 95% CI 1.1-2.0) and BPD (adjusted OR 1.9, 95% CI 1.1-3.2) were significantly associated with respiratory morbidity. Prolonged rupture of membranes (adjusted OR 3.7, 95% CI 1.6-8.5), family history of asthma (adjusted OR 5.9, 95% CI2.7-13.0) and BPD (adjusted OR 1.8, 95% CI1.1-3.0) were significantly associated with respiratory morbidity at 5 years of age. At 19 years of age only higher social class was associated with decreased respiratory morbidity (adjusted OR 0.64, 95% CI 0.41-0.99). The areas under the curves (AUC) were 0.65, 0.71 and 0.61 respectively. The prediction models for respiratory morbidity at 2 and 5 years of age showed a good calibration, while the calibration plot for respiratory morbidity at 19 year was less optimal. Conclusions: RDS is not a risk-indicator for long-term respiratory morbidity at 2, 5 and 19 years in this cohort (OR 1.2, 95% 0.88-1.7; 1.3, 95% 0.88-2.0; OR 0.91, 95% 0.56-1.5 respectively). Future obstetric studies interested in the effect of a specific perinatal intervention on long-term respiratory morbidity, should consider taking bronchopulmonary dysplasia (BPD) as primary outcome instead of RDS. (C) 2012 Elsevier Ireland Ltd. All rights reserved
AB - Objectives: To develop prediction models for long-term respiratory morbidity. To explore if respiratory distress syndrome (RDS) is a risk-indicator for long-term respiratory morbidity and to identify other perinatal risk-indicators for long-term respiratory morbidity. Study design: In the Dutch POPS cohort 1338 live born infants delivered in The Netherlands in 1983, either before 32 completed weeks gestation and/or with a birth weight below 1500 g, were followed prospectively. We used multivariable logistic regression analyses to construct three prediction models for respiratory morbidity at 2, 5 and 19 years of age. Results: At 2 years of age, maternal smoking (adjusted OR 1.5, 95% CI 1.0-2.4), prolonged rupture of membranes (adjusted OR 2.3, 95% CI 1.3-4.1), pre-eclampsia (adjusted OR 1.9, 95% CI 1.1-4.1), male gender (adjusted OR 1.5, 95% CI 1.1-2.0) and BPD (adjusted OR 1.9, 95% CI 1.1-3.2) were significantly associated with respiratory morbidity. Prolonged rupture of membranes (adjusted OR 3.7, 95% CI 1.6-8.5), family history of asthma (adjusted OR 5.9, 95% CI2.7-13.0) and BPD (adjusted OR 1.8, 95% CI1.1-3.0) were significantly associated with respiratory morbidity at 5 years of age. At 19 years of age only higher social class was associated with decreased respiratory morbidity (adjusted OR 0.64, 95% CI 0.41-0.99). The areas under the curves (AUC) were 0.65, 0.71 and 0.61 respectively. The prediction models for respiratory morbidity at 2 and 5 years of age showed a good calibration, while the calibration plot for respiratory morbidity at 19 year was less optimal. Conclusions: RDS is not a risk-indicator for long-term respiratory morbidity at 2, 5 and 19 years in this cohort (OR 1.2, 95% 0.88-1.7; 1.3, 95% 0.88-2.0; OR 0.91, 95% 0.56-1.5 respectively). Future obstetric studies interested in the effect of a specific perinatal intervention on long-term respiratory morbidity, should consider taking bronchopulmonary dysplasia (BPD) as primary outcome instead of RDS. (C) 2012 Elsevier Ireland Ltd. All rights reserved
U2 - https://doi.org/10.1016/j.ejogrb.2012.04.015
DO - https://doi.org/10.1016/j.ejogrb.2012.04.015
M3 - Article
C2 - 22579229
SN - 0301-2115
VL - 163
SP - 134
EP - 141
JO - European journal of obstetrics, gynecology, and reproductive biology
JF - European journal of obstetrics, gynecology, and reproductive biology
IS - 2
ER -