TY - CHAP
T1 - Peroxisomes and their central role in metabolic interaction networks in humans
AU - Wanders, Ronald J. A.
AU - Waterham, Hans R.
AU - Ferdinandusse, Sacha
PY - 2018
Y1 - 2018
N2 - Peroxisomes catalyze a number of essential metabolic functions and impairments in any of these are usually associated with major clinical signs and symptoms. In contrast to mitochondria which are autonomous organelles that can catalyze the degradation of fatty acids, certain amino acids and other compounds all by themselves, peroxisomes are non-autonomous organelles which are highly dependent on the interaction with other organelles and compartments to fulfill their role in metabolism. This includes mitochondria, the endoplasmic reticulum, lysosomes, and the cytosol. In this paper we will discuss the central role of peroxisomes in different metabolic interaction networks in humans, including fatty acid oxidation, ether phospholipid biosynthesis, bile acid synthesis, fatty acid alpha-oxidation and glyoxylate metabolism.
AB - Peroxisomes catalyze a number of essential metabolic functions and impairments in any of these are usually associated with major clinical signs and symptoms. In contrast to mitochondria which are autonomous organelles that can catalyze the degradation of fatty acids, certain amino acids and other compounds all by themselves, peroxisomes are non-autonomous organelles which are highly dependent on the interaction with other organelles and compartments to fulfill their role in metabolism. This includes mitochondria, the endoplasmic reticulum, lysosomes, and the cytosol. In this paper we will discuss the central role of peroxisomes in different metabolic interaction networks in humans, including fatty acid oxidation, ether phospholipid biosynthesis, bile acid synthesis, fatty acid alpha-oxidation and glyoxylate metabolism.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85055666619&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30378031
U2 - https://doi.org/10.1007/978-981-13-2233-4_15
DO - https://doi.org/10.1007/978-981-13-2233-4_15
M3 - Chapter
C2 - 30378031
VL - 89
T3 - Subcellular Biochemistry
SP - 345
EP - 365
BT - Subcellular Biochemistry
PB - Springer New York
ER -