Peroxisomes, lipid metabolism and lipotoxicity

R. J. A. Wanders; S. Ferdinandusse; P. Brites; S. Kemp

doi:https://doi.org/10.1016/j.bbalip.2010.01.001

Peroxisomes, lipid metabolism and lipotoxicity

R. J. A. Wanders, S. Ferdinandusse, P. Brites, S. Kemp

Research output: Contribution to journal › Review article › Academic › peer-review

132 Citations (Scopus)

Abstract

Peroxisomes play an essential role in cellular lipid metabolism as exemplified by the existence of a number of genetic diseases in humans caused by the impaired function of one of the peroxisomal enzymes involved in lipid metabolism. Key pathways in which peroxisomes are involved include: (1.) fatty acid beta-oxidation; (2.) etherphospholipid biosynthesis, and (3.) fatty acid alpha-oxidation. In this paper we will describe these different pathways in some detail and will provide an overview of peroxisomal disorders of metabolism and in addition discuss the toxicity of the intermediates of peroxisomal metabolism as they accumulate in the different peroxisomal deficiencies. (C) 2010 Elsevier B.V. All rights reserved

Original language	English
Pages (from-to)	272-280
Journal	BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Volume	1801
Issue number	3
DOIs	https://doi.org/10.1016/j.bbalip.2010.01.001
Publication status	Published - 2010

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https://doi.org/10.1016/j.bbalip.2010.01.001

Cite this

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title = "Peroxisomes, lipid metabolism and lipotoxicity",

abstract = "Peroxisomes play an essential role in cellular lipid metabolism as exemplified by the existence of a number of genetic diseases in humans caused by the impaired function of one of the peroxisomal enzymes involved in lipid metabolism. Key pathways in which peroxisomes are involved include: (1.) fatty acid beta-oxidation; (2.) etherphospholipid biosynthesis, and (3.) fatty acid alpha-oxidation. In this paper we will describe these different pathways in some detail and will provide an overview of peroxisomal disorders of metabolism and in addition discuss the toxicity of the intermediates of peroxisomal metabolism as they accumulate in the different peroxisomal deficiencies. (C) 2010 Elsevier B.V. All rights reserved",

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AU - Wanders, R. J. A.

AU - Ferdinandusse, S.

AU - Brites, P.

AU - Kemp, S.

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N2 - Peroxisomes play an essential role in cellular lipid metabolism as exemplified by the existence of a number of genetic diseases in humans caused by the impaired function of one of the peroxisomal enzymes involved in lipid metabolism. Key pathways in which peroxisomes are involved include: (1.) fatty acid beta-oxidation; (2.) etherphospholipid biosynthesis, and (3.) fatty acid alpha-oxidation. In this paper we will describe these different pathways in some detail and will provide an overview of peroxisomal disorders of metabolism and in addition discuss the toxicity of the intermediates of peroxisomal metabolism as they accumulate in the different peroxisomal deficiencies. (C) 2010 Elsevier B.V. All rights reserved

AB - Peroxisomes play an essential role in cellular lipid metabolism as exemplified by the existence of a number of genetic diseases in humans caused by the impaired function of one of the peroxisomal enzymes involved in lipid metabolism. Key pathways in which peroxisomes are involved include: (1.) fatty acid beta-oxidation; (2.) etherphospholipid biosynthesis, and (3.) fatty acid alpha-oxidation. In this paper we will describe these different pathways in some detail and will provide an overview of peroxisomal disorders of metabolism and in addition discuss the toxicity of the intermediates of peroxisomal metabolism as they accumulate in the different peroxisomal deficiencies. (C) 2010 Elsevier B.V. All rights reserved

U2 - https://doi.org/10.1016/j.bbalip.2010.01.001

DO - https://doi.org/10.1016/j.bbalip.2010.01.001

M3 - Review article

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SN - 1388-1981

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JO - BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

JF - BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

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