Pharmacogenetics of ACE inhibitor-induced angioedema and cough: a systematic review and meta-analysis

Seyed Hamidreza Mahmoudpour; Maarten Leusink; Lisa van der Putten; Ingrid Terreehorst; Folkert W. Asselbergs; Anthonius de Boer; Anke H. Maitland-van der Zee

doi:https://doi.org/10.2217/PGS.12.206

Pharmacogenetics of ACE inhibitor-induced angioedema and cough: a systematic review and meta-analysis

Seyed Hamidreza Mahmoudpour, Maarten Leusink, Lisa van der Putten, Ingrid Terreehorst, Folkert W. Asselbergs, Anthonius de Boer, Anke H. Maitland-van der Zee

Research output: Contribution to journal › Review article › Academic › peer-review

52 Citations (Scopus)

Abstract

Angioedema and cough are the two most important adverse effects of ACE inhibitors (ACEIs). Evidence exists that ACEI-related angioedema/cough is partly genetically determined and several genes have been identified to play a role in the development of ACEI-related adverse effects. This study was performed in order to evaluate the evidence of these genetic associations and ACEIs' adverse effects. After removing duplicates and critical appraisal, 19 studies were considered to be eligible to review; 14 articles about cough and five articles about angioedema. A separate meta-analysis was performed for the most studied ACE insertion/deletion polymorphism (rs4646994) and its association with cough. One gene region (XPNPEP2) was associated with ACEI-induced angioedema in three studies. In our meta-analysis we did not find a significant association between the ACE insertion/deletion polymorphism and ACEI cough

Original language	English
Pages (from-to)	249-260
Journal	Pharmacogenomics
Volume	14
Issue number	3
DOIs	https://doi.org/10.2217/PGS.12.206
Publication status	Published - 2013

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https://doi.org/10.2217/PGS.12.206

Cite this

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title = "Pharmacogenetics of ACE inhibitor-induced angioedema and cough: a systematic review and meta-analysis",

abstract = "Angioedema and cough are the two most important adverse effects of ACE inhibitors (ACEIs). Evidence exists that ACEI-related angioedema/cough is partly genetically determined and several genes have been identified to play a role in the development of ACEI-related adverse effects. This study was performed in order to evaluate the evidence of these genetic associations and ACEIs' adverse effects. After removing duplicates and critical appraisal, 19 studies were considered to be eligible to review; 14 articles about cough and five articles about angioedema. A separate meta-analysis was performed for the most studied ACE insertion/deletion polymorphism (rs4646994) and its association with cough. One gene region (XPNPEP2) was associated with ACEI-induced angioedema in three studies. In our meta-analysis we did not find a significant association between the ACE insertion/deletion polymorphism and ACEI cough",

author = "Mahmoudpour, {Seyed Hamidreza} and Maarten Leusink and {van der Putten}, Lisa and Ingrid Terreehorst and Asselbergs, {Folkert W.} and {de Boer}, Anthonius and {Maitland-van der Zee}, {Anke H.}",

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T1 - Pharmacogenetics of ACE inhibitor-induced angioedema and cough: a systematic review and meta-analysis

AU - Mahmoudpour, Seyed Hamidreza

AU - Leusink, Maarten

AU - van der Putten, Lisa

AU - Terreehorst, Ingrid

AU - Asselbergs, Folkert W.

AU - de Boer, Anthonius

AU - Maitland-van der Zee, Anke H.

PY - 2013

Y1 - 2013

N2 - Angioedema and cough are the two most important adverse effects of ACE inhibitors (ACEIs). Evidence exists that ACEI-related angioedema/cough is partly genetically determined and several genes have been identified to play a role in the development of ACEI-related adverse effects. This study was performed in order to evaluate the evidence of these genetic associations and ACEIs' adverse effects. After removing duplicates and critical appraisal, 19 studies were considered to be eligible to review; 14 articles about cough and five articles about angioedema. A separate meta-analysis was performed for the most studied ACE insertion/deletion polymorphism (rs4646994) and its association with cough. One gene region (XPNPEP2) was associated with ACEI-induced angioedema in three studies. In our meta-analysis we did not find a significant association between the ACE insertion/deletion polymorphism and ACEI cough

AB - Angioedema and cough are the two most important adverse effects of ACE inhibitors (ACEIs). Evidence exists that ACEI-related angioedema/cough is partly genetically determined and several genes have been identified to play a role in the development of ACEI-related adverse effects. This study was performed in order to evaluate the evidence of these genetic associations and ACEIs' adverse effects. After removing duplicates and critical appraisal, 19 studies were considered to be eligible to review; 14 articles about cough and five articles about angioedema. A separate meta-analysis was performed for the most studied ACE insertion/deletion polymorphism (rs4646994) and its association with cough. One gene region (XPNPEP2) was associated with ACEI-induced angioedema in three studies. In our meta-analysis we did not find a significant association between the ACE insertion/deletion polymorphism and ACEI cough

U2 - https://doi.org/10.2217/PGS.12.206

DO - https://doi.org/10.2217/PGS.12.206

M3 - Review article

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JO - Pharmacogenomics

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