Pharmacokinetic interaction between raltegravir and rifampicin in an infant with HIV exposed to active TB: a case report

Marlotte A. A. van der Veer; Tom G. Jacobs; Laura H. Bukkems; Angela P. H. Colbers; David M. Burger; Henriette J. Scherpbier; Yuma A. Bijleveld

doi:https://doi.org/10.1177/13596535221119932

Pharmacokinetic interaction between raltegravir and rifampicin in an infant with HIV exposed to active TB: a case report

Marlotte A. A. van der Veer, Tom G. Jacobs, Laura H. Bukkems, Angela P. H. Colbers, David M. Burger, Henriette J. Scherpbier, Yuma A. Bijleveld

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

We report a case of an infant with HIV receiving raltegravir granules for oral suspension and rifampicin-based TB prophylaxis. Raltegravir trough levels remained subtherapeutic and viral load increased during concurrent rifampicin therapy despite using double-dosed raltegravir. Even after rifampicin therapy, a higher dose was needed. This highlights the importance of therapeutic drug monitoring and dose adjustments of raltegravir in infants with rifampicin as comedication.

Original language	English
Journal	Antiviral therapy
Volume	27
Issue number	4
DOIs	https://doi.org/10.1177/13596535221119932
Publication status	Published - 1 Aug 2022

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title = "Pharmacokinetic interaction between raltegravir and rifampicin in an infant with HIV exposed to active TB: a case report",

abstract = "We report a case of an infant with HIV receiving raltegravir granules for oral suspension and rifampicin-based TB prophylaxis. Raltegravir trough levels remained subtherapeutic and viral load increased during concurrent rifampicin therapy despite using double-dosed raltegravir. Even after rifampicin therapy, a higher dose was needed. This highlights the importance of therapeutic drug monitoring and dose adjustments of raltegravir in infants with rifampicin as comedication.",

author = "{van der Veer}, {Marlotte A. A.} and Jacobs, {Tom G.} and Bukkems, {Laura H.} and Colbers, {Angela P. H.} and Burger, {David M.} and Scherpbier, {Henriette J.} and Bijleveld, {Yuma A.}",

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T2 - a case report

AU - van der Veer, Marlotte A. A.

AU - Jacobs, Tom G.

AU - Bukkems, Laura H.

AU - Colbers, Angela P. H.

AU - Burger, David M.

AU - Scherpbier, Henriette J.

AU - Bijleveld, Yuma A.

PY - 2022/8/1

Y1 - 2022/8/1

N2 - We report a case of an infant with HIV receiving raltegravir granules for oral suspension and rifampicin-based TB prophylaxis. Raltegravir trough levels remained subtherapeutic and viral load increased during concurrent rifampicin therapy despite using double-dosed raltegravir. Even after rifampicin therapy, a higher dose was needed. This highlights the importance of therapeutic drug monitoring and dose adjustments of raltegravir in infants with rifampicin as comedication.

AB - We report a case of an infant with HIV receiving raltegravir granules for oral suspension and rifampicin-based TB prophylaxis. Raltegravir trough levels remained subtherapeutic and viral load increased during concurrent rifampicin therapy despite using double-dosed raltegravir. Even after rifampicin therapy, a higher dose was needed. This highlights the importance of therapeutic drug monitoring and dose adjustments of raltegravir in infants with rifampicin as comedication.

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DO - https://doi.org/10.1177/13596535221119932

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VL - 27

JO - Antiviral therapy

JF - Antiviral therapy

IS - 4

ER -

Pharmacokinetic interaction between raltegravir and rifampicin in an infant with HIV exposed to active TB: a case report

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