Phosphorylation at endothelial cell-cell junctions: Implications for VE-cadherin function

Ilse Timmerman; Peter L. Hordijk; Jaap D. van Buul

Phosphorylation at endothelial cell-cell junctions: Implications for VE-cadherin function

Ilse Timmerman, Peter L. Hordijk, Jaap D. van Buul

Research output: Contribution to journal › Review article › Academic › peer-review

3 Citations (Scopus)

Abstract

Endothelial cell-cell junctions are strictly regulated in order to control the barrier function of endothelium. Vascular endothelial (VE)-cadherin is one of the proteins that is crucial in this process. It has been reported that phosphorylation events control the function of VE-cadherin. This review summarizes the role of VE-cadherin phosphorylation in the regulation of endothelial cell-cell junctions and highlights how this affects vascular permeability and leukocyte extravasation.

Original language	English
Pages (from-to)	23-31
Number of pages	9
Journal	Cell Health and Cytoskeleton
Volume	2
Issue number	1
Publication status	Published - 23 Nov 2010

Keywords

Barrier
Endothelium
Junctions
Phosphorylation
VE-cadherin

Cite this

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title = "Phosphorylation at endothelial cell-cell junctions: Implications for VE-cadherin function",

abstract = "Endothelial cell-cell junctions are strictly regulated in order to control the barrier function of endothelium. Vascular endothelial (VE)-cadherin is one of the proteins that is crucial in this process. It has been reported that phosphorylation events control the function of VE-cadherin. This review summarizes the role of VE-cadherin phosphorylation in the regulation of endothelial cell-cell junctions and highlights how this affects vascular permeability and leukocyte extravasation.",

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T2 - Implications for VE-cadherin function

AU - Timmerman, Ilse

AU - Hordijk, Peter L.

AU - van Buul, Jaap D.

PY - 2010/11/23

Y1 - 2010/11/23

N2 - Endothelial cell-cell junctions are strictly regulated in order to control the barrier function of endothelium. Vascular endothelial (VE)-cadherin is one of the proteins that is crucial in this process. It has been reported that phosphorylation events control the function of VE-cadherin. This review summarizes the role of VE-cadherin phosphorylation in the regulation of endothelial cell-cell junctions and highlights how this affects vascular permeability and leukocyte extravasation.

AB - Endothelial cell-cell junctions are strictly regulated in order to control the barrier function of endothelium. Vascular endothelial (VE)-cadherin is one of the proteins that is crucial in this process. It has been reported that phosphorylation events control the function of VE-cadherin. This review summarizes the role of VE-cadherin phosphorylation in the regulation of endothelial cell-cell junctions and highlights how this affects vascular permeability and leukocyte extravasation.

KW - Barrier

KW - Endothelium

KW - Junctions

KW - Phosphorylation

KW - VE-cadherin

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M3 - Review article

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JO - Cell Health and Cytoskeleton

JF - Cell Health and Cytoskeleton

IS - 1

ER -

Phosphorylation at endothelial cell-cell junctions: Implications for VE-cadherin function

Abstract

Keywords

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