Phylogenetic analysis reveals three distinct epidemiological profiles in Dutch and Flemish blood donors with hepatitis B virus infection

Thijs J. van de Laar; Véronique A. van Gaever; Peter van Swieten; An Muylaert; Veerle Compernolle; Hans L. Zaaijer

doi:https://doi.org/10.1016/j.virol.2017.12.011

Phylogenetic analysis reveals three distinct epidemiological profiles in Dutch and Flemish blood donors with hepatitis B virus infection

Thijs J. van de Laar, Véronique A. van Gaever, Peter van Swieten, An Muylaert, Veerle Compernolle, Hans L. Zaaijer

Research output: Contribution to journal › Article › Academic › peer-review

5 Citations (Scopus)

Abstract

During 2006-2016, hepatitis B virus (HBV) was detected in nearly 400 blood donors in the Netherlands and Flanders. Donor demographics and self-reported risk factors as disclosed during the donor exit interview were compared to HBV phylogenies of donor and reference sequences. First-time donors with chronic HBV-infection were often immigrants (67%) infected with genetically highly diverse strains of genotypes A (32%), B (8%), C (6%), D (53%) and E to H (1%). Each subtype was strongly associated with donor ethnicity. In contrast, 57/62 (93%) of acute/recent HBV infections occurred among indigenous donors, of whom 67% was infected with one specific widely circulating epidemic HBV-A2 lineage. HBV typing identified three distinct epidemiological profiles: the import of chronic HBV infections through migration, longstanding transmission of non-epidemic HBV-A2 strains within western-Europe, and the active transmission of one epidemic HBV-A2 strain most likely fueled by sexual risk behavior

Original language	English
Pages (from-to)	243-249
Journal	Virology
Volume	515
DOIs	https://doi.org/10.1016/j.virol.2017.12.011
Publication status	Published - 2018

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https://doi.org/10.1016/j.virol.2017.12.011

Cite this

@article{01697c3368f04601a48ead160296f0e4,

title = "Phylogenetic analysis reveals three distinct epidemiological profiles in Dutch and Flemish blood donors with hepatitis B virus infection",

abstract = "During 2006-2016, hepatitis B virus (HBV) was detected in nearly 400 blood donors in the Netherlands and Flanders. Donor demographics and self-reported risk factors as disclosed during the donor exit interview were compared to HBV phylogenies of donor and reference sequences. First-time donors with chronic HBV-infection were often immigrants (67%) infected with genetically highly diverse strains of genotypes A (32%), B (8%), C (6%), D (53%) and E to H (1%). Each subtype was strongly associated with donor ethnicity. In contrast, 57/62 (93%) of acute/recent HBV infections occurred among indigenous donors, of whom 67% was infected with one specific widely circulating epidemic HBV-A2 lineage. HBV typing identified three distinct epidemiological profiles: the import of chronic HBV infections through migration, longstanding transmission of non-epidemic HBV-A2 strains within western-Europe, and the active transmission of one epidemic HBV-A2 strain most likely fueled by sexual risk behavior",

author = "{van de Laar}, {Thijs J.} and {van Gaever}, {V{\'e}ronique A.} and {van Swieten}, Peter and An Muylaert and Veerle Compernolle and Zaaijer, {Hans L.}",

year = "2018",

doi = "https://doi.org/10.1016/j.virol.2017.12.011",

language = "English",

volume = "515",

pages = "243--249",

journal = "Virology",

issn = "0042-6822",

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T1 - Phylogenetic analysis reveals three distinct epidemiological profiles in Dutch and Flemish blood donors with hepatitis B virus infection

AU - van de Laar, Thijs J.

AU - van Gaever, Véronique A.

AU - van Swieten, Peter

AU - Muylaert, An

AU - Compernolle, Veerle

AU - Zaaijer, Hans L.

PY - 2018

Y1 - 2018

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AB - During 2006-2016, hepatitis B virus (HBV) was detected in nearly 400 blood donors in the Netherlands and Flanders. Donor demographics and self-reported risk factors as disclosed during the donor exit interview were compared to HBV phylogenies of donor and reference sequences. First-time donors with chronic HBV-infection were often immigrants (67%) infected with genetically highly diverse strains of genotypes A (32%), B (8%), C (6%), D (53%) and E to H (1%). Each subtype was strongly associated with donor ethnicity. In contrast, 57/62 (93%) of acute/recent HBV infections occurred among indigenous donors, of whom 67% was infected with one specific widely circulating epidemic HBV-A2 lineage. HBV typing identified three distinct epidemiological profiles: the import of chronic HBV infections through migration, longstanding transmission of non-epidemic HBV-A2 strains within western-Europe, and the active transmission of one epidemic HBV-A2 strain most likely fueled by sexual risk behavior

U2 - https://doi.org/10.1016/j.virol.2017.12.011

DO - https://doi.org/10.1016/j.virol.2017.12.011

M3 - Article

C2 - 29324289

SN - 0042-6822

VL - 515

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JO - Virology

JF - Virology

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