TY - JOUR
T1 - Physical Training and Healthy Diet Improved Bowel Symptoms, Quality of Life, and Fatigue in Children with Inflammatory Bowel Disease
AU - Scheffers, Linda Elisabeth
AU - Vos, Iris K.
AU - Utens, E. M. W. J.
AU - Dieleman, G. C.
AU - Walet, S.
AU - Escher, J. C.
AU - van den Berg, L. E. M.
AU - Rotterdam Exercise Team
N1 - Funding Information: Sources of Funding: This study was supported by the “Stichting Vrienden van Sophia,” grant number: B19-01. Publisher Copyright: © 2023 Lippincott Williams and Wilkins. All rights reserved.
PY - 2023/8/1
Y1 - 2023/8/1
N2 - Objectives: Physical activity programs have been suggested as adjunctive therapy in adult inflammatory bowel disease (IBD) patients. We assessed the effects of a 12-week lifestyle intervention in children with IBD. Methods: This study was a randomized semi-crossover controlled trial, investigating a 12-week lifestyle program (3 physical training sessions per week plus personalized healthy dietary advice) in children with IBD. Endpoints were physical fitness (maximal and submaximal exercise capacity, strength, and core stability), patient-reported outcomes (quality of life, fatigue, and fears for exercise), clinical disease activity (fecal calprotectin and disease activity scores), and nutritional status (energy balance and body composition). Change in maximal exercise capacity (peak VO2) was the primary endpoint; all others were secondary endpoints. Results: Fifteen patients (median age 15 [IQR: 12-16]) completed the program. At baseline, peak VO2was reduced (median 73.3% [58.8-100.9] of predicted). After the 12-week program, compared to the control period, peak VO2did not change significantly; exercise capacity measured by 6-minute walking test and core-stability did. While medical treatment remained unchanged, Pediatric Crohn's Disease Activity Index decreased significantly versus the control period (15 [3-25] vs 2.5 [0-5], P = 0.012), and fecal calprotectin also decreased significantly but not versus the control period. Quality of life (IMPACT-III) improved on 4 out of 6 domains and total score (+13 points) versus the control period. Parents-reported quality of life on the child health questionnaire and total fatigue score (PedsQoL Multidimensional Fatigue Scale) also improved significantly versus the control period. Conclusions: A 12-week lifestyle intervention improved bowel symptoms, quality of life, and fatigue in pediatric IBD patients.
AB - Objectives: Physical activity programs have been suggested as adjunctive therapy in adult inflammatory bowel disease (IBD) patients. We assessed the effects of a 12-week lifestyle intervention in children with IBD. Methods: This study was a randomized semi-crossover controlled trial, investigating a 12-week lifestyle program (3 physical training sessions per week plus personalized healthy dietary advice) in children with IBD. Endpoints were physical fitness (maximal and submaximal exercise capacity, strength, and core stability), patient-reported outcomes (quality of life, fatigue, and fears for exercise), clinical disease activity (fecal calprotectin and disease activity scores), and nutritional status (energy balance and body composition). Change in maximal exercise capacity (peak VO2) was the primary endpoint; all others were secondary endpoints. Results: Fifteen patients (median age 15 [IQR: 12-16]) completed the program. At baseline, peak VO2was reduced (median 73.3% [58.8-100.9] of predicted). After the 12-week program, compared to the control period, peak VO2did not change significantly; exercise capacity measured by 6-minute walking test and core-stability did. While medical treatment remained unchanged, Pediatric Crohn's Disease Activity Index decreased significantly versus the control period (15 [3-25] vs 2.5 [0-5], P = 0.012), and fecal calprotectin also decreased significantly but not versus the control period. Quality of life (IMPACT-III) improved on 4 out of 6 domains and total score (+13 points) versus the control period. Parents-reported quality of life on the child health questionnaire and total fatigue score (PedsQoL Multidimensional Fatigue Scale) also improved significantly versus the control period. Conclusions: A 12-week lifestyle intervention improved bowel symptoms, quality of life, and fatigue in pediatric IBD patients.
KW - Adolescent
KW - Adult
KW - Child
KW - Crohn disease
KW - Diet, Healthy
KW - Exercise
KW - Fatigue/etiology
KW - Humans
KW - Inflammatory Bowel Diseases/complications
KW - Quality of Life
KW - inflammatory bowel disease
KW - pediatrics
KW - physical exercise
KW - ulcerative colitis
UR - http://www.scopus.com/inward/record.url?scp=85169329143&partnerID=8YFLogxK
UR - https://pure.uva.nl/ws/files/150331799/mpg_1_1_2023_04_25_scheffers_jpgn-22-799_sdc1.pdf
U2 - https://doi.org/10.1097/MPG.0000000000003816
DO - https://doi.org/10.1097/MPG.0000000000003816
M3 - Article
C2 - 37134004
SN - 0277-2116
VL - 77
SP - 214
EP - 221
JO - Journal of pediatric gastroenterology and nutrition
JF - Journal of pediatric gastroenterology and nutrition
IS - 2
ER -