Pitfalls when comparing COVID-19-related outcomes across studies-lessons learnt from the ERACODA collaboration

Marlies Noordzij; Priya Vart; Raphaël Duivenvoorden; Casper F M Franssen; Marc H Hemmelder; Kitty J Jager; Luuk B Hilbrands; Ron T Gansevoort

doi:https://doi.org/10.1093/ckj/sfab027

Pitfalls when comparing COVID-19-related outcomes across studies-lessons learnt from the ERACODA collaboration

Marlies Noordzij, Priya Vart, Raphaël Duivenvoorden, Casper F M Franssen, Marc H Hemmelder, Kitty J Jager, Luuk B Hilbrands, Ron T Gansevoort

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

Reported outcomes, such as incidence rates of mortality and intensive care unit admission, vary widely across epidemiological coronavirus disease 2019 (COVID-19) studies, including in the nephrology field. This variation can in part be explained by differences in patient characteristics, but also methodological aspects must be considered. In this review, we reflect on the methodological factors that contribute to the observed variation in COVID-19-related outcomes and their risk factors that are identified in the various studies. We focus on issues that arose during the design and analysis phase of the European Renal Association COVID-19 Database (ERACODA), and use examples from recently published reports on COVID-19 to illustrate these issues.

Original language	English
Pages (from-to)	i14-i20
Journal	Clinical Kidney Journal
Volume	14
Issue number	Suppl 1
DOIs	https://doi.org/10.1093/ckj/sfab027
Publication status	Published - Mar 2021

Access to Document

https://doi.org/10.1093/ckj/sfab027

Cite this

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title = "Pitfalls when comparing COVID-19-related outcomes across studies-lessons learnt from the ERACODA collaboration",

abstract = "Reported outcomes, such as incidence rates of mortality and intensive care unit admission, vary widely across epidemiological coronavirus disease 2019 (COVID-19) studies, including in the nephrology field. This variation can in part be explained by differences in patient characteristics, but also methodological aspects must be considered. In this review, we reflect on the methodological factors that contribute to the observed variation in COVID-19-related outcomes and their risk factors that are identified in the various studies. We focus on issues that arose during the design and analysis phase of the European Renal Association COVID-19 Database (ERACODA), and use examples from recently published reports on COVID-19 to illustrate these issues.",

author = "Marlies Noordzij and Priya Vart and Rapha{\"e}l Duivenvoorden and Franssen, {Casper F M} and Hemmelder, {Marc H} and Jager, {Kitty J} and Hilbrands, {Luuk B} and Gansevoort, {Ron T}",

year = "2021",

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language = "English",

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T1 - Pitfalls when comparing COVID-19-related outcomes across studies-lessons learnt from the ERACODA collaboration

AU - Noordzij, Marlies

AU - Vart, Priya

AU - Duivenvoorden, Raphaël

AU - Franssen, Casper F M

AU - Hemmelder, Marc H

AU - Jager, Kitty J

AU - Hilbrands, Luuk B

AU - Gansevoort, Ron T

PY - 2021/3

Y1 - 2021/3

N2 - Reported outcomes, such as incidence rates of mortality and intensive care unit admission, vary widely across epidemiological coronavirus disease 2019 (COVID-19) studies, including in the nephrology field. This variation can in part be explained by differences in patient characteristics, but also methodological aspects must be considered. In this review, we reflect on the methodological factors that contribute to the observed variation in COVID-19-related outcomes and their risk factors that are identified in the various studies. We focus on issues that arose during the design and analysis phase of the European Renal Association COVID-19 Database (ERACODA), and use examples from recently published reports on COVID-19 to illustrate these issues.

AB - Reported outcomes, such as incidence rates of mortality and intensive care unit admission, vary widely across epidemiological coronavirus disease 2019 (COVID-19) studies, including in the nephrology field. This variation can in part be explained by differences in patient characteristics, but also methodological aspects must be considered. In this review, we reflect on the methodological factors that contribute to the observed variation in COVID-19-related outcomes and their risk factors that are identified in the various studies. We focus on issues that arose during the design and analysis phase of the European Renal Association COVID-19 Database (ERACODA), and use examples from recently published reports on COVID-19 to illustrate these issues.

U2 - https://doi.org/10.1093/ckj/sfab027

DO - https://doi.org/10.1093/ckj/sfab027

M3 - Review article

C2 - 33796283

SN - 2048-8505

VL - 14

SP - i14-i20

JO - Clinical Kidney Journal

JF - Clinical Kidney Journal

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