TY - JOUR
T1 - Plasma Cholesteryl Ester Fatty Acids do not Mediate the Association of Ethnicity with Type 2 Diabetes
T2 - Results From the HELIUS Study
AU - Muilwijk, Mirthe
AU - Celis-Morales, Carlos
AU - Nicolaou, Mary
AU - Snijder, Marieke B.
AU - Gill, Jason M. R.
AU - van Valkengoed, Irene G. M.
N1 - Funding Information: JG and IGMV contributed equally to this work. MM, CC, MN, JG, and IGMV designed the study. MBS established the HELIUS study cohort and managed the data. MM conducted the analyses and wrote the manuscript. IGMV contributed to the writing. CC, MN, MBS, JG, and IGMV reviewed the manuscript. All authors read and approved the final manuscript. This work was sponsored by the Health Programme 2014–2020 from the European Union, grant number 664609 HP-PJ-2014. HELIUS was funded by the Dutch Heart Foundation, the Netherlands Organization for Health Research and Development (ZonMw), and the European Union (FP-7). We thank Michel Hof for his statistical support. Publisher Copyright: © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2018/1
Y1 - 2018/1
N2 - Scope: Ethnic minority groups have a higher risk of type 2 diabetes (T2D) than the host population. Our aim is to identify whether plasma cholesteryl ester fatty acids (CEFA) mediate the ethnic differences in type 2 diabetes. Methods and results: We included 202 Dutch, 206 South-Asian Surinamese, 205 African Surinamese, 215 Turkish, and 213 Moroccan origin participants of the HELIUS study (Amsterdam, the Netherlands). Logistic regression is used to determine the associations between plasma CEFA and T2D. Mediation analysis is used to identify whether CEFA contributed to the association between ethnicity and T2D. We adjusted for ethnicity, age, sex, smoking, physical activity, and BMI. Associations between plasma CEFA and T2D were similar across all ethnic groups. Although differences in plasma CEFA across ethnic groups were observed, CEFA did not mediate the differences in T2D prevalence between ethnic groups. Conclusion: Although ethnic differences in plasma CEFA are found and CEFA are associated with T2D, CEFA does not contribute to the difference in T2D prevalence between ethnic groups. If confirmed, this implies that maintenance of the more beneficial CEFA profiles in the non-Dutch ethnic groups may be encouraged to prevent an even higher prevalence of T2D in these groups
AB - Scope: Ethnic minority groups have a higher risk of type 2 diabetes (T2D) than the host population. Our aim is to identify whether plasma cholesteryl ester fatty acids (CEFA) mediate the ethnic differences in type 2 diabetes. Methods and results: We included 202 Dutch, 206 South-Asian Surinamese, 205 African Surinamese, 215 Turkish, and 213 Moroccan origin participants of the HELIUS study (Amsterdam, the Netherlands). Logistic regression is used to determine the associations between plasma CEFA and T2D. Mediation analysis is used to identify whether CEFA contributed to the association between ethnicity and T2D. We adjusted for ethnicity, age, sex, smoking, physical activity, and BMI. Associations between plasma CEFA and T2D were similar across all ethnic groups. Although differences in plasma CEFA across ethnic groups were observed, CEFA did not mediate the differences in T2D prevalence between ethnic groups. Conclusion: Although ethnic differences in plasma CEFA are found and CEFA are associated with T2D, CEFA does not contribute to the difference in T2D prevalence between ethnic groups. If confirmed, this implies that maintenance of the more beneficial CEFA profiles in the non-Dutch ethnic groups may be encouraged to prevent an even higher prevalence of T2D in these groups
KW - ethnicity
KW - fatty acids
KW - non-insulin-dependent diabetes mellitus
KW - type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85040824936&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/mnfr.201700528
DO - https://doi.org/10.1002/mnfr.201700528
M3 - Article
C2 - 28981995
SN - 1613-4125
VL - 62
SP - 1700528
JO - Molecular nutrition & food research
JF - Molecular nutrition & food research
IS - 2
M1 - 1700528
ER -