Plasma hepatocyte growth factor as a marker for small-for-gestational age fetuses

May Lee Tjoa; Monique A M Mulders; John M G van Vugt; Marinus A Blankenstein; Cees B M Oudejans; Inge J van Wijk

Plasma hepatocyte growth factor as a marker for small-for-gestational age fetuses

May Lee Tjoa, Monique A M Mulders, John M G van Vugt, Marinus A Blankenstein, Cees B M Oudejans, Inge J van Wijk

Research output: Contribution to journal › Article › Academic › peer-review

9 Citations (Scopus)

Abstract

OBJECTIVE: To study the association between hepatocyte growth factor (HGF) levels and pregnancy outcome.

STUDY DESIGN: Hepatocyte growth factor levels were measured in 42 plasma samples between weeks 14 and 21 of gestation using an enzyme-linked immunosorbent assay (ELISA). Results were correlated to pregnancy outcome and Mann-Whitney U-test applied to study the differences.

RESULTS: Hepatocyte growth factor values in pregnancies that develop preeclampsia (n=12) were not significantly different from unaffected pregnancies (n=21, multiples of the median (MoM)=1.38, P=0.47). However, hepatocyte growth factor values were significantly elevated in pregnancies of small-for-gestational age (SGA) fetuses (n=9) compared to uncomplicated pregnancies (MoM=2.66, P<0.001).

CONCLUSION: Measurement of hepatocyte growth factor in peripheral blood between 14 and 21 weeks gestation may offer new possibilities in the early diagnosis and prediction of fetal birth weight but not of preeclampsia.

Original language	English
Pages (from-to)	20-5
Number of pages	6
Journal	European Journal of Obstetrics and Gynecology and Reproductive Biology
Volume	110
Issue number	1
Publication status	Published - 10 Sept 2003

Keywords

Biomarkers/blood
Enzyme-Linked Immunosorbent Assay
Female
Gestational Age
Hepatocyte Growth Factor/blood
Humans
Infant, Newborn
Infant, Small for Gestational Age
Pre-Eclampsia/blood
Pregnancy
Pregnancy Outcome

Cite this

@article{4528d1ad17d5480b80f0a6fb73830812,

title = "Plasma hepatocyte growth factor as a marker for small-for-gestational age fetuses",

abstract = "OBJECTIVE: To study the association between hepatocyte growth factor (HGF) levels and pregnancy outcome.STUDY DESIGN: Hepatocyte growth factor levels were measured in 42 plasma samples between weeks 14 and 21 of gestation using an enzyme-linked immunosorbent assay (ELISA). Results were correlated to pregnancy outcome and Mann-Whitney U-test applied to study the differences.RESULTS: Hepatocyte growth factor values in pregnancies that develop preeclampsia (n=12) were not significantly different from unaffected pregnancies (n=21, multiples of the median (MoM)=1.38, P=0.47). However, hepatocyte growth factor values were significantly elevated in pregnancies of small-for-gestational age (SGA) fetuses (n=9) compared to uncomplicated pregnancies (MoM=2.66, P<0.001).CONCLUSION: Measurement of hepatocyte growth factor in peripheral blood between 14 and 21 weeks gestation may offer new possibilities in the early diagnosis and prediction of fetal birth weight but not of preeclampsia.",

keywords = "Biomarkers/blood, Enzyme-Linked Immunosorbent Assay, Female, Gestational Age, Hepatocyte Growth Factor/blood, Humans, Infant, Newborn, Infant, Small for Gestational Age, Pre-Eclampsia/blood, Pregnancy, Pregnancy Outcome",

author = "Tjoa, {May Lee} and Mulders, {Monique A M} and {van Vugt}, {John M G} and Blankenstein, {Marinus A} and Oudejans, {Cees B M} and {van Wijk}, {Inge J}",

year = "2003",

month = sep,

day = "10",

language = "English",

volume = "110",

pages = "20--5",

journal = "European Journal of Obstetrics and Gynecology and Reproductive Biology",

issn = "0301-2115",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Plasma hepatocyte growth factor as a marker for small-for-gestational age fetuses

AU - Tjoa, May Lee

AU - Mulders, Monique A M

AU - van Vugt, John M G

AU - Blankenstein, Marinus A

AU - Oudejans, Cees B M

AU - van Wijk, Inge J

PY - 2003/9/10

Y1 - 2003/9/10

N2 - OBJECTIVE: To study the association between hepatocyte growth factor (HGF) levels and pregnancy outcome.STUDY DESIGN: Hepatocyte growth factor levels were measured in 42 plasma samples between weeks 14 and 21 of gestation using an enzyme-linked immunosorbent assay (ELISA). Results were correlated to pregnancy outcome and Mann-Whitney U-test applied to study the differences.RESULTS: Hepatocyte growth factor values in pregnancies that develop preeclampsia (n=12) were not significantly different from unaffected pregnancies (n=21, multiples of the median (MoM)=1.38, P=0.47). However, hepatocyte growth factor values were significantly elevated in pregnancies of small-for-gestational age (SGA) fetuses (n=9) compared to uncomplicated pregnancies (MoM=2.66, P<0.001).CONCLUSION: Measurement of hepatocyte growth factor in peripheral blood between 14 and 21 weeks gestation may offer new possibilities in the early diagnosis and prediction of fetal birth weight but not of preeclampsia.

AB - OBJECTIVE: To study the association between hepatocyte growth factor (HGF) levels and pregnancy outcome.STUDY DESIGN: Hepatocyte growth factor levels were measured in 42 plasma samples between weeks 14 and 21 of gestation using an enzyme-linked immunosorbent assay (ELISA). Results were correlated to pregnancy outcome and Mann-Whitney U-test applied to study the differences.RESULTS: Hepatocyte growth factor values in pregnancies that develop preeclampsia (n=12) were not significantly different from unaffected pregnancies (n=21, multiples of the median (MoM)=1.38, P=0.47). However, hepatocyte growth factor values were significantly elevated in pregnancies of small-for-gestational age (SGA) fetuses (n=9) compared to uncomplicated pregnancies (MoM=2.66, P<0.001).CONCLUSION: Measurement of hepatocyte growth factor in peripheral blood between 14 and 21 weeks gestation may offer new possibilities in the early diagnosis and prediction of fetal birth weight but not of preeclampsia.

KW - Biomarkers/blood

KW - Enzyme-Linked Immunosorbent Assay

KW - Female

KW - Gestational Age

KW - Hepatocyte Growth Factor/blood

KW - Humans

KW - Infant, Newborn

KW - Infant, Small for Gestational Age

KW - Pre-Eclampsia/blood

KW - Pregnancy

KW - Pregnancy Outcome

M3 - Article

C2 - 12932865

SN - 0301-2115

VL - 110

SP - 20

EP - 25

JO - European Journal of Obstetrics and Gynecology and Reproductive Biology

JF - European Journal of Obstetrics and Gynecology and Reproductive Biology

IS - 1

ER -