TY - JOUR
T1 - Plasma HIV-1 RNA to guide patient selection for antiretroviral therapy in resource-poor settings
T2 - Efficiency related to active case finding
AU - Bogaards, Johannes A.
AU - Weverling, Gerrit Jan
AU - Zwinderman, Aeilko H.
AU - Bossuyt, Patrick M.M.
AU - Goudsmit, Jaap
PY - 2006/2
Y1 - 2006/2
N2 - Scaling up access to highly active antiretroviral therapy (HAART) requires eligibility criteria that safeguard treatment efficiency in resource-poor settings. We determined whether supply of HAART on the basis of plasma viral load testing could result in a stronger reduction of AIDS incidence as compared with CD4 count-driven strategies. Expected AIDS incidence rates corresponding to distinct HAART eligibility criteria were calculated by relying on risk parameters obtained through the Amsterdam cohort studies on HIV infection and AIDS. We modeled 2 different treatment settings derived from sub-Saharan African surveys. In a hospital-based setting, the reduction in the 1-year AIDS incidence is the same for any HAART administration rate if patients are selected on a single CD4 cell count criterion or on (additional) criteria for plasma HIV-1 RNA. In a community-based setting, where patients are identified at less advanced stages of infection, the reduction in the 1-year AIDS incidence is higher at particular HAART administration rates if patients are selected on criteria for plasma HIV-1 RNA rather than CD4 cell count. Plasma viral load testing can ensure a more efficient allocation of antiretroviral therapy but only when applied to a strategy of active case finding in the community.
AB - Scaling up access to highly active antiretroviral therapy (HAART) requires eligibility criteria that safeguard treatment efficiency in resource-poor settings. We determined whether supply of HAART on the basis of plasma viral load testing could result in a stronger reduction of AIDS incidence as compared with CD4 count-driven strategies. Expected AIDS incidence rates corresponding to distinct HAART eligibility criteria were calculated by relying on risk parameters obtained through the Amsterdam cohort studies on HIV infection and AIDS. We modeled 2 different treatment settings derived from sub-Saharan African surveys. In a hospital-based setting, the reduction in the 1-year AIDS incidence is the same for any HAART administration rate if patients are selected on a single CD4 cell count criterion or on (additional) criteria for plasma HIV-1 RNA. In a community-based setting, where patients are identified at less advanced stages of infection, the reduction in the 1-year AIDS incidence is higher at particular HAART administration rates if patients are selected on criteria for plasma HIV-1 RNA rather than CD4 cell count. Plasma viral load testing can ensure a more efficient allocation of antiretroviral therapy but only when applied to a strategy of active case finding in the community.
KW - Antiretroviral therapy
KW - CD4
KW - Epidemiology
KW - HIV diagnostic tests
KW - Resource-poor settings
KW - Virus load
UR - http://www.scopus.com/inward/record.url?scp=33645324471&partnerID=8YFLogxK
U2 - https://doi.org/10.1097/01.qai.0000179457.46809.42
DO - https://doi.org/10.1097/01.qai.0000179457.46809.42
M3 - Article
C2 - 16394857
SN - 1525-4135
VL - 41
SP - 232
EP - 237
JO - JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
JF - JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
IS - 2
ER -