TY - JOUR
T1 - Plasma monoamine metabolites and aggression
T2 - Two studies of normal and oppositional defiant disorder children
AU - Van Goozen, Stephanie H M
AU - Matthys, Walter
AU - Cohen-Kettenis, Peggy T.
AU - Westenberg, Herman
AU - Van Engeland, Herman
PY - 1999/1/1
Y1 - 1999/1/1
N2 - In two studies the relationship between plasma monoamine metabolites and different parameters of aggression were examined in children suffering from severe aggression and antisocial behavior. No prior studies have related measures of serotonergic function to experimentally elicited aggression and only a few included healthy comparison groups. Plasma 5-HIAA, HVA and MHPG were measured in 15 boys with a oppositional defiant disorder (ODD) and 25 normal controls (NC) (study 1), and 22 ODD and 25 NC children (study 2). On a separate occasion each subject had the opportunity to behave aggressively towards an opponent. 5-HIAA and HVA were significantly lower in the ODD than NC group and both parameters were significantly inversely correlated with aggression and delinquency. These findings were replicated in the second study. The results of the study support a role for serotonergic functioning in persistent antisocial and aggressive behavior in young children.
AB - In two studies the relationship between plasma monoamine metabolites and different parameters of aggression were examined in children suffering from severe aggression and antisocial behavior. No prior studies have related measures of serotonergic function to experimentally elicited aggression and only a few included healthy comparison groups. Plasma 5-HIAA, HVA and MHPG were measured in 15 boys with a oppositional defiant disorder (ODD) and 25 normal controls (NC) (study 1), and 22 ODD and 25 NC children (study 2). On a separate occasion each subject had the opportunity to behave aggressively towards an opponent. 5-HIAA and HVA were significantly lower in the ODD than NC group and both parameters were significantly inversely correlated with aggression and delinquency. These findings were replicated in the second study. The results of the study support a role for serotonergic functioning in persistent antisocial and aggressive behavior in young children.
KW - Aggression
KW - Child psychiatry
KW - Monoamine metabolites
KW - Serotonin
UR - http://www.scopus.com/inward/record.url?scp=0032970135&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/S0924-977X(98)00019-4
DO - https://doi.org/10.1016/S0924-977X(98)00019-4
M3 - Article
C2 - 10082240
SN - 0924-977X
VL - 9
SP - 141
EP - 147
JO - European neuropsychopharmacology
JF - European neuropsychopharmacology
IS - 1-2
ER -