TY - JOUR
T1 - Plasma Transfusion and Procoagulant Product Administration in Extracorporeal Membrane Oxygenation
T2 - A Secondary Analysis of an International Observational Study on Current Practices
AU - van Haeren, Maite M. T.
AU - Raasveld, Senta Jorinde
AU - Karami, Mina
AU - Miranda, Dinis Dos Reis
AU - Mandigers, Loes
AU - Dauwe, Dieter F.
AU - de Troy, Erwin
AU - Pappalardo, Federico
AU - Fominskiy, Evgeny
AU - van den Bergh, Walter M.
AU - Oude Lansink-Hartgring, Annemieke
AU - van der Velde, Franciska
AU - Maas, Jacinta J.
AU - van de Berg, Pablo
AU - de Haan, Maarten
AU - Donker, Dirk W.
AU - Meuwese, Christiaan L.
AU - Taccone, Fabio Silvio
AU - Peluso, Lorenzo
AU - Lorusso, Roberto
AU - Delnoij, Thijs S. R.
AU - Scholten, Erik
AU - Overmars, Martijn
AU - Ivancan, Višnja
AU - Bojčić, Robert
AU - de Metz, Jesse
AU - van den Bogaard, Bas
AU - de Bakker, Martin
AU - Reddi, Benjamin
AU - Hermans, Greet
AU - Broman, Lars Mikael
AU - Henriques, José P. S.
AU - Schenk, Jimmy
AU - Vlaar, Alexander P. J.
AU - Müller, Marcella C. A.
N1 - Publisher Copyright: © 2023 The Author(s).
PY - 2023/8/21
Y1 - 2023/8/21
N2 - OBJECTIVES: To achieve optimal hemostatic balance in patients on extracorporeal membrane oxygenation (ECMO), a liberal transfusion practice is currently applied despite clear evidence. We aimed to give an overview of the current use of plasma, fibrinogen concentrate, tranexamic acid (TXA), and prothrombin complex concentrate (PCC) in patients on ECMO. DESIGN: A prespecified subanalysis of a multicenter retrospective study. Venovenous (VV)-ECMO and venoarterial (VA)-ECMO are analyzed as separate populations, comparing patients with and without bleeding and with and without thrombotic complications. SETTING: Sixteen international ICUs. PATIENTS: Adult patients on VA-ECMO or VV-ECMO. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Of 420 VA-ECMO patients, 59% (n = 247) received plasma, 20% (n = 82) received fibrinogen concentrate, 17% (n = 70) received TXA, and 7% of patients (n = 28) received PCC. Fifty percent of patients (n = 208) suffered bleeding complications and 27% (n = 112) suffered thrombotic complications. More patients with bleeding complications than patients without bleeding complications received plasma (77% vs. 41%, p < 0.001), fibrinogen concentrate (28% vs 11%, p < 0.001), and TXA (23% vs 10%, p < 0.001). More patients with than without thrombotic complications received TXA (24% vs 14%, p = 0.02, odds ratio 1.75) in VA-ECMO, where no difference was seen in VV-ECMO. Of 205 VV-ECMO patients, 40% (n = 81) received plasma, 6% (n = 12) fibrinogen concentrate, 7% (n = 14) TXA, and 5% (n = 10) PCC. Thirty-nine percent (n = 80) of VV-ECMO patients suffered bleeding complications and 23% (n = 48) of patients suffered thrombotic complications. More patients with than without bleeding complications received plasma (58% vs 28%, p < 0.001), fibrinogen concentrate (13% vs 2%, p < 0.01), and TXA (11% vs 2%, p < 0.01). CONCLUSIONS: The majority of patients on ECMO receive transfusions of plasma, procoagulant products, or antifibrinolytics. In a significant part of the plasma transfused patients, this was in the absence of bleeding or prolonged international normalized ratio. This poses the question if these plasma transfusions were administered for another indication or could have been avoided.
AB - OBJECTIVES: To achieve optimal hemostatic balance in patients on extracorporeal membrane oxygenation (ECMO), a liberal transfusion practice is currently applied despite clear evidence. We aimed to give an overview of the current use of plasma, fibrinogen concentrate, tranexamic acid (TXA), and prothrombin complex concentrate (PCC) in patients on ECMO. DESIGN: A prespecified subanalysis of a multicenter retrospective study. Venovenous (VV)-ECMO and venoarterial (VA)-ECMO are analyzed as separate populations, comparing patients with and without bleeding and with and without thrombotic complications. SETTING: Sixteen international ICUs. PATIENTS: Adult patients on VA-ECMO or VV-ECMO. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Of 420 VA-ECMO patients, 59% (n = 247) received plasma, 20% (n = 82) received fibrinogen concentrate, 17% (n = 70) received TXA, and 7% of patients (n = 28) received PCC. Fifty percent of patients (n = 208) suffered bleeding complications and 27% (n = 112) suffered thrombotic complications. More patients with bleeding complications than patients without bleeding complications received plasma (77% vs. 41%, p < 0.001), fibrinogen concentrate (28% vs 11%, p < 0.001), and TXA (23% vs 10%, p < 0.001). More patients with than without thrombotic complications received TXA (24% vs 14%, p = 0.02, odds ratio 1.75) in VA-ECMO, where no difference was seen in VV-ECMO. Of 205 VV-ECMO patients, 40% (n = 81) received plasma, 6% (n = 12) fibrinogen concentrate, 7% (n = 14) TXA, and 5% (n = 10) PCC. Thirty-nine percent (n = 80) of VV-ECMO patients suffered bleeding complications and 23% (n = 48) of patients suffered thrombotic complications. More patients with than without bleeding complications received plasma (58% vs 28%, p < 0.001), fibrinogen concentrate (13% vs 2%, p < 0.01), and TXA (11% vs 2%, p < 0.01). CONCLUSIONS: The majority of patients on ECMO receive transfusions of plasma, procoagulant products, or antifibrinolytics. In a significant part of the plasma transfused patients, this was in the absence of bleeding or prolonged international normalized ratio. This poses the question if these plasma transfusions were administered for another indication or could have been avoided.
KW - blood coagulation factors
KW - coagulants
KW - extracorporeal membrane oxygenation
KW - fibrinogen
KW - plasma
KW - transfusion
UR - http://www.scopus.com/inward/record.url?scp=85170207242&partnerID=8YFLogxK
U2 - https://doi.org/10.1097/CCE.0000000000000949
DO - https://doi.org/10.1097/CCE.0000000000000949
M3 - Article
C2 - 37614800
SN - 2639-8028
VL - 5
SP - E0949
JO - Critical Care Explorations
JF - Critical Care Explorations
IS - 8
ER -