Plasma tumor necrosis factor-a (TNF-a) levels in Gaucher disease

H. Michelakakis; C. Spanou; A. Kondyli; E. Dimitriou; S. van Weely; C. E. Hollak; M. H. van Oers; J. M. Aerts

doi:https://doi.org/10.1016/S0925-4439(96)00056-7

Plasma tumor necrosis factor-a (TNF-a) levels in Gaucher disease

H. Michelakakis, C. Spanou, A. Kondyli, E. Dimitriou, S. van Weely, C. E. Hollak, M. H. van Oers, J. M. Aerts

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Abstract

Tumor necrosis factor-a (TNF-a) levels were measured in the plasma of patients with different types of Gaucher disease (GD) and patients with other lysosomal storage diseases. The highest TNF-a levels were observed in the most severe neuronopathic type of GD, exceeding those found in healthy individuals as well as patients with other lysosomal disorders. Type I GD cases showed a wide range of TNF-a levels ranging from normal to 2.5 x the highest control value. TNF-a is a pleiotropic cytokine produced mainly by activated macrophages. Our data suggest that it may play a role in the pathophysiology of GD disease

Original language	English
Pages (from-to)	219-222
Journal	Biochimica et Biophysica Acta-Molecular Basis of Disease
Volume	1317
Issue number	3
DOIs	https://doi.org/10.1016/S0925-4439(96)00056-7
Publication status	Published - 1996

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https://doi.org/10.1016/S0925-4439(96)00056-7

Cite this

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title = "Plasma tumor necrosis factor-a (TNF-a) levels in Gaucher disease",

abstract = "Tumor necrosis factor-a (TNF-a) levels were measured in the plasma of patients with different types of Gaucher disease (GD) and patients with other lysosomal storage diseases. The highest TNF-a levels were observed in the most severe neuronopathic type of GD, exceeding those found in healthy individuals as well as patients with other lysosomal disorders. Type I GD cases showed a wide range of TNF-a levels ranging from normal to 2.5 x the highest control value. TNF-a is a pleiotropic cytokine produced mainly by activated macrophages. Our data suggest that it may play a role in the pathophysiology of GD disease",

author = "H. Michelakakis and C. Spanou and A. Kondyli and E. Dimitriou and {van Weely}, S. and Hollak, {C. E.} and {van Oers}, {M. H.} and Aerts, {J. M.}",

year = "1996",

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T1 - Plasma tumor necrosis factor-a (TNF-a) levels in Gaucher disease

AU - Michelakakis, H.

AU - Spanou, C.

AU - Kondyli, A.

AU - Dimitriou, E.

AU - van Weely, S.

AU - Hollak, C. E.

AU - van Oers, M. H.

AU - Aerts, J. M.

PY - 1996

Y1 - 1996

N2 - Tumor necrosis factor-a (TNF-a) levels were measured in the plasma of patients with different types of Gaucher disease (GD) and patients with other lysosomal storage diseases. The highest TNF-a levels were observed in the most severe neuronopathic type of GD, exceeding those found in healthy individuals as well as patients with other lysosomal disorders. Type I GD cases showed a wide range of TNF-a levels ranging from normal to 2.5 x the highest control value. TNF-a is a pleiotropic cytokine produced mainly by activated macrophages. Our data suggest that it may play a role in the pathophysiology of GD disease

AB - Tumor necrosis factor-a (TNF-a) levels were measured in the plasma of patients with different types of Gaucher disease (GD) and patients with other lysosomal storage diseases. The highest TNF-a levels were observed in the most severe neuronopathic type of GD, exceeding those found in healthy individuals as well as patients with other lysosomal disorders. Type I GD cases showed a wide range of TNF-a levels ranging from normal to 2.5 x the highest control value. TNF-a is a pleiotropic cytokine produced mainly by activated macrophages. Our data suggest that it may play a role in the pathophysiology of GD disease

U2 - https://doi.org/10.1016/S0925-4439(96)00056-7

DO - https://doi.org/10.1016/S0925-4439(96)00056-7

M3 - Article

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SP - 219

EP - 222

JO - Biochimica et Biophysica Acta-Molecular Basis of Disease

JF - Biochimica et Biophysica Acta-Molecular Basis of Disease

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